Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01459-0005-0000-6
Chemical Name:	4,4'-Diamino-2,2'-stilbenedisulfonic acid
CASRN:	81-11-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	636704
Vehicle Control:	95% Ethanol
Study Result:	Negative

View Study Details | View Protocol | Download To Excel | View Summary Data | View Detailed Data

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	130	12.8	126	9.4	136	5.6	132	11.9	146	3.3	143	1.7
100	124	4.5	120	6.9	128	3.7	126	11.6	142	1.9	136	1.5
333	138	3.5	163	30.4	132	5.5	142	4.4	151	6.7	146	6.7
1000	137	9	134	1.2	148	7.8	143	5.6	150	12.1	141	5.8
3333	120	.7	138	3.8	125	3.8	144	7.1	140	5.9	147	8
5000	138	11.4	150	4.9	148	8.2	156	8.9	152	6.7	126	8
Positive Control	864	.9	1053	36.7	888	17	775	44.7	949	23.2	1014	18.6

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	22	3.7	34	1.8	16	1.5	16	1.5	14	2.3	19	.9
100	24	3.5	25	1.7	19	3	19	3.2	15	2.3	26	2.8
333	22	4.1	24	2.5	21	1.5	18	5.2	19	1.8	17	3.4
1000	22	2	27	3.1	22	2.8	17	2.9	17	2.7	19	2
3333	22	2.7	27	4.6	22	2.3	16	2.5	18	4.1	21	1.8
5000	24	2.9	24	2.6	20	1.9	26	2.9	16	3.8	15	1.5
Positive Control	719	6.4	847	15	50	3.2	99	13.1	49	7.9	89	12.7

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	1.2	6	1.5	8	1	5	.3	7	2	7	.6
100	4	.9	4	1.7	7	2.1	3	.3	5	1.2	5	2
333	6	1.5	3	.9	6	1.3	8	1.7	4	.6	6	2.8
1000	8	.7	8	.7	7	2.5	6	1.2	5	1.9	4	1.5
3333	3	.6	5	.3	4	1.2	8	.9	6	1.2	8	1.8
5000	6	2.7	4	1.2	7	.7	7	.3	8	2.8	6	1.3
Positive Control	255	3.2	312	69.5	54	2.3	41	5.7	59	7.8	95	18.3

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Equivocal)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	17	1.5	20	.3	18	2.3	26	3.5	30	2.2	29	1.2	32	4	28	3.5	31	4.3
100	21	2					25	1.7					28	2.4
333	19	1.9			18	3.8	27	.3			30	7.2	24	1.2			25	.7
1000	22	1.5			21	.9	28	3.2			23	2.5	32	2.1			30	2.3
3000			19	1.5					29	2.1					41	5.2
3333	18	1.2			21	2.6	30	.6			34	1.5	37	.9			29	2.9
3500			20	1.5					29	1.9					36	1.9
4000			19	1.9	25	.9			34	2.4	40	4			40	2.7	34	3.8
4500			17	1.5	27	3			36	2.3	33	3.3			33	2.3	36	5.7
5000	20	1.9	18	1.9	24	2.4	34	1.9	40	4.1	32	5.9	61	2.6	35	2	38	.9
Positive Control	1236	24.8	1430	72.1	1221	5	911	49.5	831	20.5	411	17.5	875	14.5	1241	88.1	1023	26.4

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;