Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01485-0006-0000-6
Chemical Name:	4-Biphenylamine
CASRN:	92-67-1
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	797992
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Positive

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Positive)		10% RLI (Positive)		10% HLI (Positive)		10% HLI (Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	129	3.7	130	5.5	159	3.1	147	9.3	166	10.2	172	16.1
3.3	125	7.8	101	14.4	289	11.5	258	14.5	409	11.3	539	58.3
10	123	.3	120	2	573	47	563	67.2	913	44.6	1106	94.7
33	102	13.4	109	5.2	1208	2.7	975	94.8	1250	28	1684	196.2
100	111	1.5	117	5.7	1627	45.6	1232	145.1	1585	14.8	1831	106.8
333	105	8.4	86	11.3	1573	25.8	1238	113.8	1810	65.9	1973	64.1
Positive Control	444	44.8	451	20.9	429	37.5	442	38.1	894	121.6	1135	74.5

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		No Activation (Negative)		10% RLI (Equivocal)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Weakly Positive)		10% HLI (Weakly Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	12	2	12	1.5	11	1.3	14	2.8	17	1.3	17	3.3	9	.9	9	0	10	2.4
3.3	11	1.8	12	1.8			18	2.7	18	2.7			9	.6	18	5.7
10	12	.7	13	1.2			20	1.2	18	3.1			9	.6	19	5
33	11	2.5	14	1.8	13	1.5	25	.7	20	5	25	3.5	14	1.5	22	3.8	28	.6
66					9	.6					28	4.6					32	2.1
100	8	2.3	8	0	5	1.2	21	1.3	18	3.7	25	3.7	11	2.6	22	5.8	27	.3
166					4	.6					17	4.9					29	2.1
333	6	1.2	3	1.5	2	.6	19	0	16	7	20	2.2	14	1.9	18	2.4	27	2.3
Positive Control	534	19	559	14.9	682	32.5	41	6.3	38	1.5	40	6.1	80	8.1	99	4.9	79	7.5

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Positive)		10% RLI (Positive)		10% HLI (Positive)		10% HLI (Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	5	.7	7	1.5	10	.3	9	.7	9	1.2	8	1.5
3.3	5	.6	5	.9	13	1.2	9	2	8	1.7	13	4.1
10	6	1.2	6	1.8	15	2	17	2.4	14	1.5	20	4.1
33	4	1	5	1	28	2.4	32	2.8	40	4.1	41	2.3
100	3	.7	4	.3	31	2.6	41	7.2	38	2.8	49	7.5
333	3	.9	5	.5	38	3.2	44	5.5	27	.9	26	3.1
Positive Control	118	17	215	36.4	25	6.3	31	3	68	8.2	76	14.2

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Positive)		10% RLI (Positive)		10% HLI (Positive)		10% HLI (Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	12	1.2	18	3.2	26	1.8	32	3.8	25	2.1	32	3.8
3.3	9	2.3	20	3.5	54	6.5	92	13.2	84	5.7	118	11.3
10	11	2.2	20	2.6	173	19.6	276	43.3	259	26	276	33.2
33	14	.3	20	1.2	367	8.8	552	84.9	484	27.7	435	97.5
100	9	1.5	13	.3	669	22.3	720	80.1	776	9	497	55.9
333	9	2	11	1.5	769	44.8	847	142.2	1030	30.2	598	99.1
Positive Control	187	1.3	268	18.9	280	30	303	10.5	730	27.9	992	120

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;