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Study Information
Study Attribute Value
CEBS Accession Number: 002-02712-0001-0000-5
Chemical Name: Polystyrene
CASRN: 9003-53-6
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: A14107
Vehicle Control: Methyl Ethyl Ketone
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Standard Plate Incorporation Preincubation Standard Plate Incorporation Preincubation Standard Plate Incorporation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 101 2 103 2.7 108 2.6 124 4.5 133 6.4 104 .6 147 9.2 110 1.2 0 0 
 0         
 101 2 103 2.7 108 2.6 124 4.5 133 6.4 104 .6 147 9.2 110 1.2 0 0 
10         
 99 3.1 137 2.8 135 16.9 
33         
 108 2.6 129 9.9 128 12.2 
100         
 99 5.3 98 3.1 98 4.1 121 5 116 3.2 104 5.8 132 5.2 105 4.3 101 2.9 
333         
 104 1.9 101 4.6 104 .6 106 10.3 123 6 105 2.6 117 2.8 110 7.2 109 1.8 
1000         
 102 5 100 7.4 102 3.2 110 10.4 121 2.2 96 4 128 6.7 112 7 117 3.5 
3333         
 100 2.5 106 2.8 104 3.1 115 4.5 122 4.1 103 2.9 123 7 109 4.9 112 5.7 
10000         
 105 p 2.3 74 p 3.5 109 p .9 124 p 11.7 124 p 3.7 109 p 17.1 130 p 3.5 112 p 13.2 100 p 8.2
Positive Control 837 10.2 855 13.7 1009 32.4 327 12.7 1148 42.7 352 11.7 625 6.7 358 12.4 322 10.6

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 7 .3 10 1.7 9 .9 10 .9 13 .7 11 1 
100         
 6 .9 10 2.6 8 .6 10 1.5 11 2 10 1.7 
333         
 11 2 15 .3 8 1.9 9 1.5 9 1.5 11 1.8 
1000         
 7 .7 9 1.2 8 2 8 .6 10 1.2 10 1.5 
3333         
 7 .9 13 .6 9 .3 8 .6 10 .6 9 1.2 
10000         
 9 p 0 11 p .3 9 p .3 11 p 1.2 11 p 1.3 11 p 1.5
Positive Control 922 7.5 839 35 145 6.8 223 7.2 92 2.6 81 1.5

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 119 6.2 120 4.3 142 3.5 141 26.7 143 9.6 135 7.1 
100         
 110 8.5 118 10.1 142 2 119 4.9 148 5.2 137 9.3 
333         
 116 3.8 131 11.1 129 6.2 110 14 137 .3 146 4.9 
1000         
 120 10.7 117 6.2 124 11.7 118 8.5 138 4.4 137 5.2 
3333         
 107 3.8 122 7.3 129 7.2 123 4.9 159 8.6 129 2.6 
10000         
 105 p 4.8 112 p 5.5 127 p 9.7 143 p 29.2 134 p 3.6 135 p 8.8
Positive Control 407 19.1 453 32.4 352 10.4 391 3.8 330 16.4 319 11.7

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Standard Plate Incorporation Preincubation Standard Plate Incorporation Preincubation Standard Plate Incorporation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 15 2.8 13 2.6 23 2.9 16 2 21 2.1 19 .7 22 5.2 18 3 18 1.7 
10         
 16 2.2 20 2.6 17 1.7 
33         
 16 .9 22 2.5 16 1.9 
100         
 14 .3 14 3.6 16 1 12 4 13 2.3 12 2.7 15 1.3 12 3.3 21 3.7 
333         
 12 2 11 1.3 12 2.6 19 3.8 13 .3 13 1 16 1.8 16 2.6 15 3.8 
1000         
 12 2 13 .9 14 3.8 14 .6 18 1.7 13 3.2 13 1 16 2.2 14 2 
3333         
 11 1.5 16 .3 12 1.2 16 .9 13 .7 15 1.8 16 .6 15 1 16 2.1 
10000         
 13 p 2.3 12 p 1.8 15 p .7 16 p 1.2 15 p 1.2 13 p 2.6 16 p .9 15 p 2.2 16 p 2
Positive Control 318 8.4 317 3.6 356 12.7 245 4.3 785 22.8 263 7.8 367 23.6 272 27 331 6.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;