Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01834-0001-0000-9
Chemical Name:	Carbonyl sulfide
CASRN:	463-58-1
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	A35125
Vehicle Control:	Solvent
Study Result:	Weakly Positive

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)
Protocol	Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	120	5.7	134	3.1	145	8.8
0.58	118	5.4	128	1	138	5.5
1.15	126	1.5	138	6.7	134	5.3
1.73	120	6.4	134	2.6	132	10.8
2.31	112	3.2	127	1.2	134	7.2
2.89	59 s	20.3	48 s	20.2	81 s	15.6
Positive Control	920	19.5	538	19.5	626	15.5

Strain: TA1535
Dose	No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)
Protocol	Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	16	2.2	18	.9	19	1.2
0.58	17	1.3	19	.3	19	0
1.15	17	1.2	14	1.2	20	.7
1.73	13	1	17	1.2	19	2.6
2.31	15	2.5	14	2.7	21	3.4
2.89	2 s	1.5	5 s	2	2 x	2
Positive Control	930	10.1	175	12.7	157	7.3

Strain: TA97
Dose	No Activation (Weakly Positive)		No Activation (Weakly Positive)		30% RLI (Positive)		30% RLI (Weakly Positive)		30% HLI (Weakly Positive)		30% HLI (Weakly Positive)		10% RLI (Equivocal)		10% HLI (Weakly Positive)
Protocol	Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	163	3.8	204	11	194	8.3	201	2.4	199	9.3	204	3.5	200	11.3	204	14.4
0.58	209	5.3	256	27.7	286	13.3	239	7.2	219	27.2	258	14	258	7.5	238	6.7
1.15	259	2	340	24.8	374	14.2	312	8.5	333	18.6	314	4.9	284	6.8	263	3.7
1.73	253	8.4	362	23.6	388	32.7	331	12.1	370	13	353	27.1	265	16.5	305	13
2.31	273	1	379	1.2	341	63.2	353	9	387	2.8	421	18.3	287	8.4	324	13
2.89	251	10.3	153 s	23.9	122 s	16.6	260	5.5	254	19.9	346	13.6	126 s	17	250	24.3
Positive Control	441	21.2	533	32.5	739	33.6	503	22.7	510	5.5	647	4	779	20.9	826	33.7

Strain: TA98
Dose	No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)
Protocol	Plate Test - Gas Chamber		Plate Test - Gas Chamber		Plate Test - Gas Chamber
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	19	1.2	23	2	25	2.3
0.58	21	1.7	20	.3	19	0
1.15	18	1.8	23	2.8	20	1
1.73	21	2	22	1.8	23	2
2.31	20	.3	25	3.7	26	1.7
2.89	3 s	1.2	9 s	3.3	9 s	.3
Positive Control	385	13	376	12.1	425	10.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;