ADME/TK Evaluation (S0829) of 1-Bromopropane (106-94-5) in F344 Rats and B6C3F1 Mice Exposed via Intravenous Injection or Dermal Application
Radiolabel Description:
Carbon-14 in the C-1 position, 1-Bromopropane, [1-14C]; Study I [13C, 14C]1-Bromopropane carbon-13 in the C-3 position, 1-Bromopropane [3-13C] 20 mg/kg combined with [14C]1-Bromopropane 0.8 mg/kg Carbon-14 in the C-1 position.
Vehicles:
Intravenous, 0.9% saline and 5% alkamuls; Dermal, ethanol.
Summary Data - Male Rats
- Dermal Single Dose (100 mg/kg, Study Duration 48 hours) (45KB)
- IV 3 min Infusion (20 mg/kg, Study Duration 48 hours, high radioactivity) (35KB)
- IV 3 min Infusion (20 mg/kg, Study Duration 48 hours, low radioactivity) (35KB)
- IV 3 min Infusion (5 mg/kg, Study Duration 48 hours) (35KB)
- IV Single Bolus Dose (100 mg/kg, Study Duration 48 hours) (37KB)
- IV Single Bolus Dose (20 mg/kg & Pretreat, Study Duration 48 hours) (66KB)
- IV Single Bolus Dose (20 mg/kg, Study Duration 48 hours, bolus injection) (38KB)
- IV Single Bolus Dose (5 mg/kg, Study Duration 48 hours, bolus injection) (38KB)
- IV Toxicokinetics for Male Rats (115KB)
- Individual Animal Data (Toxicokinetics) (14KB)
Summary Data - Male Mice
- IV Single Dose (100 mg/kg, Study Duration 48 hours) (38KB)
- IV Single Dose (20 mg/kg, Study Duration 48 hours) (47KB)
- IV Single Dose (5 mg/kg, Study Duration 48 hours) (56KB)