ADME/TK Evaluation (S0865) of Sodium Tungstate Dihydrate (10213-10-2) in Sprague-Dawley Rats and C57BL/6N Mice Exposed via Dosed Water, Gavage Administration or Intravenous Injection
Radiolabel Description:
The natural isotopic masses of the element tungsten (W) in sodium tungstate dihydrate (180, 182, 183, 184, and 186) were determined by inductively coupled plasma mass spectrometry (ICPMS).
Vehicles:
Intravenous, purified water; Oral gavage, purified water; Dosed water, purified water.
Summary Data - Female Rats
- Dosed Water Multliple Dose (0 mg/L, Pregnant Study Duration 15 days, Fetus) (32KB)
- Dosed Water Multliple Dose (560 mg/L, Pregnant Study Duration 9 days) (60KB)
- Dosed Water Multliple Dose (560 mg/L, Study Duration 14 days) (53KB)
- Gavage Multliple Dose (10 mg/kg, Study Duration 14 days) (25KB)
- IV Single Dose (1 mg/kg Time Course, Study Duration 24 hours) (29KB)
- IV Single Dose (1,10,100 mg/kg Time Course, Study Duration 24 hours) (47KB)
Summary Data - Female Mice
- Dosed Water Multliple Dose (560 mg/L, 8 Doses, Pregnant Study Duration 14 days, Fetus) (33KB)
- Dosed Water Multliple Dose (560 mg/L, 9 Doses, Pregnant Study Duration 15 days) (28KB)
- Dosed Water Multliple Dose (560 mg/L, Study Duration 14 days) (33KB)
- Gavage Multliple Dose (10 mg/kg, 9 Doses Study Duration 14 days) (24KB)
- Gavage Single Dose (1,10,100 mg/kg Time Course, Study Duration 24 hours) (44KB)
- IV Single Dose (1 mg/kg Time Course, Study Duration 24 hours) (26KB)