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National Institute of Environmental Health Sciences

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Publication Detail

Title: Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)-mRNA Targets by PAR-CLiP.

Authors: Melikishvili, Manana; Matveeva, Elena; Fondufe-Mittendorf, Yvonne

Published In Methods Mol Biol, (2017)

Abstract: There is a long list of important RNA-binding proteins (RBP) involved in different steps of gene expression through posttranscriptional modifications: pre-mRNA splicing, mRNA stabilization, polyadenylation, mRNA export from nucleus to the cytoplasm, and translation. The critical role of RNA-protein interaction necessitates a continuous identification of proteins involved in this process. Here we describe the identification of Poly-ADP-Ribose Polymerase 1 (PARP1) as an RNA binding protein involved in RNA splicing.

PubMed ID: 28695513 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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