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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Heavy metals and adult neurogenesis.

Authors: Wang, Hao; Matsushita, Megumi T

Published In Curr Opin Toxicol, (2021 Jun)

Abstract: With extensive use in industrial and agriculture applications, overexposure to heavy metals has become a global public health concern. The nervous system is vulnerable to many heavy metals, including cadmium, lead, and mercury. However, the knowledge about the underlying mechanisms of these metals' neurotoxicity is still very limited. Adult neurogenesis is a process of generating functional neurons from adult neural progenitor/stem cells (aNPCs), which plays an important role in cognitive function and olfaction. The studies of adult neurogenesis provide new insights into mechanisms of heavy metal neurotoxicity. This review summarizes the current research about the effects of heavy metals on adult neurogenesis and discusses their importance in understanding the mechanisms of heavy metals neurotoxicity, as well as challenges and future directions.

PubMed ID: 34056147 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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