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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Exploring the expanding universe of small RNAs.

Authors: Shi, Junchao; Zhou, Tong; Chen, Qi

Published In Nat Cell Biol, (2022 Apr)

Abstract: The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small nucleolar, small nuclear and vault RNAs), showing distinct biogenesis and functional principles. Here we discuss recent tools for sncRNA identification, caveats in sncRNA expression analysis and emerging methods for direct sequencing of sncRNAs and systematic mapping of RNA modifications that are integral to their function.

PubMed ID: 35414016 Exiting the NIEHS site

MeSH Terms: MicroRNAs*/genetics; RNA, Small Interfering/genetics; RNA, Small Untranslated*/genetics; RNA, Small Untranslated*/metabolism

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