The use of internet-based query data offers a novel approach to improve disease surveillance and provides timely disease information. This paper systematically reviewed the literature on infectious disease predictions using internet-based query data and climate factors, discussed the current research progress and challenges, and provided some recommendations for future studies. We searched the relevant articles in the PubMed, Scopus, and Web of Science databases between January 2000 and December 2019. We initially included studies that used internet-based query data to predict infectious disease epidemics, then we further filtered and appraised the studies that used both internet-based query data and climate factors. In total, 129 relevant papers were included in the review. The results showed that most studies used a simple descriptive approach (n=80; 62%) to detect epidemics of influenza (including influenza-like illness (ILI)) (n=88; 68%) and dengue (n=9; 7%). Most studies (n=61; 47%) purely used internet search metrics to predict the epidemics of infectious diseases, while only 3 out of the 129 papers included both climate variables and internet-based query data. Our research shows that including internet-based query data and climate variables could better predict climate-sensitive infectious disease epidemics; however, this method has not been widely used to date. Moreover, previous studies did not sufficiently consider the spatiotemporal uncertainty of infectious diseases. Our review suggests that further research should use both internet-based query and climate data to develop predictive models for climate-sensitive infectious diseases based on spatiotemporal models.