COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01006-0007-0000-6
Chemical Name: Wyeth 14,643 (WY)
CASRN: 50892-23-4
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A06279
Strain and Species: TGAC (FVB/N) HOMOZYGOUS Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1999-06-17 24 hour Female Slide Scoring Dosed-Feed Dosed-Feed x 182, 26 week
  Dose
(ppm)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.082		 Normochromatic Erythrocytes
Trend P: 0.412
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Feed 
 0         
 XF62 1000 1 3.0 1.0 1000 3 97.0 3.0 
 0         
 XF64 1000 2 2.4 2.0 1000 0 97.6 0.0 
 0         
 XF65 1000 2 3.0 2.0 1000 3 97.0 3.0 
 0         
 XF66 1000 1 3.0 1.0 1000 2 97.0 2.0 
 0         
 XF67 1000 0 2.2 0.0 1000 2 97.8 2.0 
 0         
 XF69 1000 2 3.3 2.0 1000 3 96.7 3.0 
 0         
 XF70 1000 2 3.2 2.0 1000 4 96.8 4.0 
 0         
 XF71 1000 1 2.9 1.0 1000 1 97.1 1.0 
 0         
 XF72 1000 0 2.3 0.0 1000 4 97.7 4.0 
 0         
 XF73 1000 2 3.3 2.0 1000 1 96.7 1.0 
 0         
 XF74 1000 3 2.5 3.0 1000 1 97.5 1.0
Average ± SEM   2.830 ± 0.120 1.450 ± 0.280   97.170 ± 0.120 2.180 ± 0.400
 
Test Chemical Wyeth 14,643 (WY) 
10         
 AF77 0 0 0 0.0 1000 2 97.3 2.0 
10         
 AF78 0 0 0 0.0 1000 3 97.5 3.0 
10         
 AF79 0 0 0 0.0 1000 3 97.4 3.0 
10         
 AF81 0 0 0 0.0 1000 2 97.1 2.0 
10         
 AF82 0 0 0 0.0 1000 3 97.2 3.0 
10         
 AF83 0 0 0 0.0 1000 3 97.5 3.0 
10         
 AF84 0 0 0 0.0 1000 1 97.1 1.0 
10         
 AF86 0 0 0 0.0 1000 3 97.7 3.0 
10         
 AF88 0 0 0 0.0 1000 2 97.3 2.0 
10         
 AF89 0 0 0 0.0 1000 2 97.8 2.0 
10         
 AF90 0 0 0 0.0 1000 1 97.3 1.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   97.380 ± 0.070 2.270 ± 0.240
Pairwise P     0.443
 
Test Chemical Wyeth 14,643 (WY) 
50         
 BF100 0 0 0 0.0 1000 1 97.8 1.0 
50         
 BF101 0 0 0 0.0 1000 2 97.4 2.0 
50         
 BF102 0 0 0 0.0 1000 5 98.2 5.0 
50         
 BF103 0 0 0 0.0 1000 3 97.9 3.0 
50         
 BF105 0 0 0 0.0 1000 1 97.7 1.0 
50         
 BF91 0 0 0 0.0 1000 4 97.7 4.0 
50         
 BF92 0 0 0 0.0 1000 0 97.2 0.0 
50         
 BF93 0 0 0 0.0 1000 3 97.4 3.0 
50         
 BF94 0 0 0 0.0 1000 1 97.6 1.0 
50         
 BF96 0 0 0 0.0 1000 3 97.6 3.0 
50         
 BF98 0 0 0 0.0 1000 2 97.5 2.0 
50         
 BF99 0 0 0 0.0 1000 3 97.4 3.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   97.620 ± 0.080 2.330 ± 0.410
Pairwise P     0.405
 
Test Chemical Wyeth 14,643 (WY) 
100         
 CF106 1000 6 3.0 6.0 1000 5 97.0 5.0 
100         
 CF107 1000 5 2.5 5.0 1000 1 97.5 1.0 
100         
 CF108 1000 1 2.4 1.0 1000 2 97.6 2.0 
100         
 CF109 1000 0 2.8 0.0 1000 2 97.2 2.0 
100         
 CF110 1000 3 3.3 3.0 1000 3 96.7 3.0 
100         
 CF111 1000 1 2.9 1.0 1000 3 97.1 3.0 
100         
 CF112 1000 2 2.5 2.0 1000 1 97.5 1.0 
100         
 CF114 1000 1 2.9 1.0 1000 3 97.1 3.0 
100         
 CF115 1000 2 3.1 2.0 1000 1 96.9 1.0 
100         
 CF116 1000 5 2.3 5.0 1000 5 97.7 5.0 
100         
 CF119 1000 0 2.6 0.0 1000 1 97.4 1.0 
100         
 CF120 1000 1 1.8 1.0 1000 1 98.2 1.0
Average ± SEM   2.680 ± 0.120 2.250 ± 0.590   97.330 ± 0.120 2.330 ± 0.430
Pairwise P   0.082   0.405
 

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1999-06-17 24 hour Male Slide Scoring Dosed-Feed Dosed-Feed x 182, 26 week
  Dose
(ppm)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.116		 Normochromatic Erythrocytes
Trend P: 0.111
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Feed 
 0         
 XM02 1000 1 2.3 1.0 1000 3 97.7 3.0 
 0         
 XM03 1000 1 2.9 1.0 1000 4 97.1 4.0 
 0         
 XM04 1000 3 2.8 3.0 1000 3 97.2 3.0 
 0         
 XM05 1000 2 2.7 2.0 1000 3 97.3 3.0 
 0         
 XM07 1000 2 2.5 2.0 1000 1 97.5 1.0 
 0         
 XM08 1000 1 2.7 1.0 1000 2 97.3 2.0 
 0         
 XM09 1000 0 2.4 0.0 1000 0 97.6 0.0 
 0         
 XM10 1000 3 3.3 3.0 1000 1 96.7 1.0 
 0         
 XM12 1000 3 2.3 3.0 1000 2 97.7 2.0 
 0         
 XM14 1000 2 2.2 2.0 1000 3 97.8 3.0 
 0         
 XM15 1000 1 2.5 1.0 1000 2 97.5 2.0
Average ± SEM   2.600 ± 0.100 1.730 ± 0.300   97.400 ± 0.100 2.180 ± 0.350
 
Test Chemical Wyeth 14,643 (WY) 
10         
 AM16 0 0 0 0.0 1000 2 97.2 2.0 
10         
 AM17 0 0 0 0.0 1000 1 96.9 1.0 
10         
 AM18 0 0 0 0.0 1000 2 97.1 2.0 
10         
 AM19 0 0 0 0.0 1000 0 96.9 0.0 
10         
 AM20 0 0 0 0.0 1000 3 97.3 3.0 
10         
 AM21 0 0 0 0.0 1000 3 97.4 3.0 
10         
 AM22 0 0 0 0.0 1000 2 97.7 2.0 
10         
 AM23 0 0 0 0.0 1000 2 97.3 2.0 
10         
 AM25 0 0 0 0.0 1000 2 98.0 2.0 
10         
 AM26 0 0 0 0.0 1000 2 97.3 2.0 
10         
 AM27 0 0 0 0.0 1000 2 97.4 2.0 
10         
 AM28 0 0 0 0.0 1000 0 97.8 0.0 
10         
 AM29 0 0 0 0.0 1000 4 97.3 4.0 
10         
 AM30 0 0 0 0.0 1000 3 97.9 3.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   97.390 ± 0.090 2.000 ± 0.300
Pairwise P     0.623
 
Test Chemical Wyeth 14,643 (WY) 
50         
 BM31 0 0 0 0.0 1000 3 98.2 3.0 
50         
 BM32 0 0 0 0.0 1000 4 97.8 4.0 
50         
 BM33 0 0 0 0.0 1000 2 97.1 2.0 
50         
 BM35 0 0 0 0.0 1000 3 96.9 3.0 
50         
 BM36 0 0 0 0.0 1000 7 96.9 7.0 
50         
 BM37 0 0 0 0.0 1000 1 97.6 1.0 
50         
 BM38 0 0 0 0.0 1000 3 97.2 3.0 
50         
 BM39 0 0 0 0.0 1000 5 97.5 5.0 
50         
 BM40 0 0 0 0.0 1000 3 97.2 3.0 
50         
 BM42 0 0 0 0.0 1000 2 97.7 2.0 
50         
 BM43 0 0 0 0.0 1000 4 97.1 4.0 
50         
 BM44 0 0 0 0.0 1000 1 97.0 1.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   97.350 ± 0.120 3.170 ± 0.490
Pairwise P     0.075
 
Test Chemical Wyeth 14,643 (WY) 
100         
 CM46 1000 2 3.3 2.0 1000 1 96.7 1.0 
100         
 CM47 1000 1 3.2 1.0 1000 2 96.8 2.0 
100         
 CM48 1000 1 2.9 1.0 1000 4 97.1 4.0 
100         
 CM49 1000 2 3.0 2.0 1000 1 97.0 1.0 
100         
 CM50 1000 5 3.5 5.0 1000 6 96.5 6.0 
100         
 CM51 1000 1 3.1 1.0 1000 1 96.9 1.0 
100         
 CM52 1000 3 2.8 3.0 1000 3 97.2 3.0 
100         
 CM53 1000 6 3.0 6.0 1000 4 97.0 4.0 
100         
 CM54 1000 2 2.6 2.0 1000 2 97.4 2.0 
100         
 CM55 1000 3 3.3 3.0 1000 1 96.7 1.0 
100         
 CM56 1000 1 3.1 1.0 1000 3 96.9 3.0 
100         
 CM58 1000 2 3.4 2.0 1000 5 96.6 5.0 
100         
 CM59 1000 3 2.7 3.0 1000 1 97.3 1.0 
100         
 CM60 1000 2 2.8 2.0 1000 3 97.2 3.0
Average ± SEM   3.050 ± 0.070 2.430 ± 0.400   96.950 ± 0.070 2.640 ± 0.440
Pairwise P   0.116   0.232