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Study Information
Study Attribute Value
CEBS Accession Number: 002-01006-0008-0000-7
Chemical Name: Wyeth 14,643 (WY)
CASRN: 50892-23-4
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A71798
Strain and Species: TGAC (FVB/N) HOMOZYGOUS Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2001-08-02 24 hour Male Slide Scoring Dermal Dermal x 130, 26 week
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.802		 Normochromatic Erythrocytes
Trend P: 0.034
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Acetone 
 0         
 XM121 1000 3 3.0 3.0 1000 5 97.0 5.0 
 0         
 XM122 1000 4 4.4 4.0 1000 3 95.6 3.0 
 0         
 XM124 1000 3 4.3 3.0 1000 5 95.7 5.0 
 0         
 XM125 1000 6 3.7 6.0 1000 3 96.3 3.0 
 0         
 XM126 1000 1 3.3 1.0 1000 2 96.7 2.0 
 0         
 XM127 1000 4 3.6 4.0 1000 1 96.4 1.0 
 0         
 XM129 1000 2 3.4 2.0 1000 4 96.6 4.0 
 0         
 XM130 1000 2 3.9 2.0 1000 2 96.1 2.0 
 0         
 XM131 1000 2 3.6 2.0 1000 6 96.4 6.0 
 0         
 XM132 1000 1 3.3 1.0 1000 1 96.7 1.0
Average ± SEM   3.650 ± 0.140 2.800 ± 0.490   96.350 ± 0.140 3.200 ± 0.550
 
Test Chemical Wyeth 14,643 (WY) 
2         
 AM137 0 0 0 0.0 1000 3 96.4 3.0 
2         
 AM138 0 0 0 0.0 1000 3 95.7 3.0 
2         
 AM139 0 0 0 0.0 1000 6 96.5 6.0 
2         
 AM140 0 0 0 0.0 1000 3 96.1 3.0 
2         
 AM141 0 0 0 0.0 1000 2 97.0 2.0 
2         
 AM142 0 0 0 0.0 1000 3 96.6 3.0 
2         
 AM143 0 0 0 0.0 1000 5 95.5 5.0 
2         
 AM144 0 0 0 0.0 1000 3 96.4 3.0 
2         
 AM146 0 0 0 0.0 1000 4 96.8 4.0 
2         
 AM147 0 0 0 0.0 1000 1 96.9 1.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   96.390 ± 0.160 3.300 ± 0.450
Pairwise P     0.451
 
Test Chemical Wyeth 14,643 (WY) 
10         
 BM151 0 0 0 0.0 1000 5 96.9 5.0 
10         
 BM152 0 0 0 0.0 1000 3 97.4 3.0 
10         
 BM153 0 0 0 0.0 1000 4 97.3 4.0 
10         
 BM154 0 0 0 0.0 1000 3 97.2 3.0 
10         
 BM155 0 0 0 0.0 1000 4 96.8 4.0 
10         
 BM156 0 0 0 0.0 1000 5 96.3 5.0 
10         
 BM157 0 0 0 0.0 1000 4 96.7 4.0 
10         
 BM158 0 0 0 0.0 1000 2 96.7 2.0 
10         
 BM159 0 0 0 0.0 1000 6 96.9 6.0 
10         
 BM160 0 0 0 0.0 1000 3 96.5 3.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   96.870 ± 0.110 3.900 ± 0.380
Pairwise P     0.203
 
Test Chemical Wyeth 14,643 (WY) 
20         
 CM166 1000 3 2.4 3.0 1000 3 97.6 3.0 
20         
 CM167 1000 2 3.2 2.0 1000 5 96.8 5.0 
20         
 CM168 1000 4 2.6 4.0 1000 5 97.4 5.0 
20         
 CM169 1000 1 3.7 1.0 1000 4 96.3 4.0 
20         
 CM171 1000 3 2.8 3.0 1000 6 97.2 6.0 
20         
 CM172 1000 3 4.1 3.0 1000 5 95.9 5.0 
20         
 CM173 1000 1 3.2 1.0 1000 6 96.8 6.0 
20         
 CM175 1000 2 3.0 2.0 1000 3 97.0 3.0 
20         
 CM176 1000 2 3.6 2.0 1000 8 96.4 8.0 
20         
 CM177 1000 1 2.8 1.0 1000 1 97.2 1.0
Average ± SEM   3.140 ± 0.170 2.200 ± 0.330   96.860 ± 0.170 4.600 ± 0.620
Pairwise P   0.802   0.056
 

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2001-08-03 24 hour Female Slide Scoring Dermal Dermal x 130, 26 week
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.944		 Normochromatic Erythrocytes
Trend P: 0.124
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Acetone 
 0         
 XF181 1000 2 2.6 2.0 1000 2 97.4 2.0 
 0         
 XF182 1000 3 3.5 3.0 1000 1 96.5 1.0 
 0         
 XF183 1000 6 4.1 6.0 1000 4 95.9 4.0 
 0         
 XF184 1000 2 4.3 2.0 1000 2 95.7 2.0 
 0         
 XF185 1000 4 4.6 4.0 1000 0 95.4 0.0 
 0         
 XF186 1000 3 4.2 3.0 1000 2 95.8 2.0 
 0         
 XF187 1000 2 4.4 2.0 1000 3 95.6 3.0 
 0         
 XF188 1000 4 4.1 4.0 1000 1 95.9 1.0 
 0         
 XF189 1000 5 3.4 5.0 1000 3 96.6 3.0 
 0         
 XF190 1000 9 4.4 9.0 1000 2 95.6 2.0
Average ± SEM   3.960 ± 0.190 4.000 ± 0.700   96.040 ± 0.190 2.000 ± 0.370
 
Test Chemical Wyeth 14,643 (WY) 
2         
 AF196 0 0 0 0.0 1000 5 96.9 5.0 
2         
 AF198 0 0 0 0.0 1000 4 91.0 4.0 
2         
 AF199 0 0 0 0.0 1000 2 97.9 2.0 
2         
 AF201 0 0 0 0.0 1000 2 96.4 2.0 
2         
 AF202 0 0 0 0.0 1000 2 96.8 2.0 
2         
 AF203 0 0 0 0.0 1000 2 97.6 2.0 
2         
 AF204 0 0 0 0.0 1000 1 96.2 1.0 
2         
 AF205 0 0 0 0.0 1000 4 96.6 4.0 
2         
 AF206 0 0 0 0.0 1000 3 97.2 3.0 
2         
 AF207 0 0 0 0.0 1000 6 97.3 6.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   96.390 ± 0.620 3.100 ± 0.500
Pairwise P     0.062
 
Test Chemical Wyeth 14,643 (WY) 
10         
 BF211 0 0 0 0.0 1000 2 95.6 2.0 
10         
 BF212 0 0 0 0.0 1000 2 95.9 2.0 
10         
 BF214 0 0 0 0.0 1000 3 95.0 3.0 
10         
 BF215 0 0 0 0.0 1000 6 97.0 6.0 
10         
 BF216 0 0 0 0.0 1000 4 96.3 4.0 
10         
 BF218 0 0 0 0.0 1000 3 96.8 3.0 
10         
 BF220 0 0 0 0.0 1000 2 96.2 2.0 
10         
 BF221 0 0 0 0.0 1000 5 96.0 5.0 
10         
 BF222 0 0 0 0.0 1000 0 96.1 0.0 
10         
 BF223 0 0 0 0.0 1000 2 96.4 2.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000   96.130 ± 0.180 2.900 ± 0.550
Pairwise P     0.099
 
Test Chemical Wyeth 14,643 (WY) 
20         
 CF226 1000 3 3.2 3.0 1000 3 96.8 3.0 
20         
 CF227 1000 2 2.9 2.0 1000 3 97.1 3.0 
20         
 CF228 1000 3 3.1 3.0 1000 3 96.9 3.0 
20         
 CF229 1000 1 2.7 1.0 1000 5 97.3 5.0 
20         
 CF231 1000 3 2.7 3.0 1000 2 97.3 2.0 
20         
 CF233 1000 6 3.8 6.0 1000 5 96.2 5.0 
20         
 CF234 1000 0 3.9 0.0 1000 3 96.1 3.0 
20         
 CF235 1000 1 3.5 1.0 1000 2 96.5 2.0 
20         
 CF236 1000 4 3.3 4.0 1000 5 96.7 5.0 
20         
 CF237 1000 4 46.4 4.0 1000 1 53.6 1.0
Average ± SEM   7.550 ± 4.320 2.700 ± 0.560   92.450 ± 4.320 3.200 ± 0.440
Pairwise P   0.944   0.048