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Study Information
Study Attribute Value
CEBS Accession Number: 002-01370-0001-0000-4
Chemical Name: 2-Nitroethanol
CASRN: 625-48-9
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: G625489
Strain and Species: B6C3F1 Mouse
Study Result: Male: Equivocal

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
2009-02-23 28 hour Male Flow Cytometry Gavage Gavage x 4, 4 day
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.03205777371266838		 Normochromatic Erythrocytes
Trend P: 0.21649755909293744
No. Examined Total MN Cells Percent PCE MN Cells
per 1000		 No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Saline 
 0         
 1 20000 86 1.3 4.3 1475574 2501 98.7 1.7 
 0         
 2 20000 42 1.2 2.1 1600223 2557 98.8 1.6 
 0         
 3 20000 81 1.2 4.1 1597902 2509 98.8 1.6 
 0         
 4 20000 51 1.2 2.6 1717281 2561 98.8 1.5 
 0         
 5 20000 54 1.3 2.7 1504323 2141 98.7 1.4
Average ± SEM   1.254 ± 0.033 3.140 ± 0.436   0.000 ± 0.000 1.556 ± 0.046
 
Test Chemical 2-Nitroethanol 
250         
 10 20000 48 1.5 2.4 1285593 1967 98.5 1.5 
250         
 6 20000 41 1.8 2.1 1062059 1450 98.2 1.4 
250         
 7 20000 65 1.5 3.3 1352280 2140 98.5 1.6 
250         
 8 20000 66 1.5 3.3 1275586 1775 98.5 1.4 
250         
 9 20000 42 1.7 2.1 1164399 1705 98.3 1.5
Average ± SEM   1.614 ± 0.070 2.620 ± 0.274   0.000 ± 0.000 1.467 ± 0.041
Pairwise P   1.000   0.798
 
Test Chemical 2-Nitroethanol 
500         
 11 20000 59 1.5 3.0 1324346 2100 98.5 1.6 
500         
 12 20000 53 1.5 2.7 1349944 2149 98.5 1.6 
500         
 13 20000 77 1.6 3.9 1258905 1950 98.4 1.5 
500         
 14 20000 52 1.5 2.6 1270735 1795 98.5 1.4 
500         
 15 20000 64 1.3 3.2 1537660 2364 98.7 1.5
Average ± SEM   1.469 ± 0.050 3.050 ± 0.227   0.000 ± 0.000 1.535 ± 0.032
Pairwise P   1.000   0.737
 
Test Chemical 2-Nitroethanol 
1000         
 16 20000 163 0.3 8.2 6948202 10447 99.7 1.5 
1000         
 17 20000 58 0.8 2.9 2433064 3917 99.2 1.6 
1000         
 18 20000 91 0.3 4.6 6073787 9900 99.7 1.6 
1000         
 19 17588 180 0.1 10.2 13235649 20212 99.9 1.5 
1000         
 20 20000 71 0.4 3.6 5580749 8787 99.6 1.6
Average ± SEM   0.384 ± 0.115 5.877 ± 1.418   0.000 ± 0.000 1.569 ± 0.024
Pairwise P   0.138   0.504
 
Positive Control Ethyl Methane Sulfonate 
150         
 21 20000 171 1.2 8.6 1597663 2824 98.8 1.8 
150         
 22 20000 171 1.4 8.6 1396003 2487 98.6 1.8 
150         
 23 20652 238 1.2 11.5 1732210 3565 98.8 2.1 
150         
 24 20000 233 0.9 11.7 2108670 3777 99.1 1.8 
150         
 25 20000 219 1.0 11.0 2041773 3919 99.0 1.9
Average ± SEM   1.147 ± 0.088 10.245 ± 0.702   0.000 ± 0.000 1.864 ± 0.056
Pairwise P   0.004   0.001