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Study Information
Study Attribute Value
CEBS Accession Number: 002-01370-0003-0000-6
Chemical Name: 2-Nitroethanol
CASRN: 625-48-9
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 666177
Vehicle Control: Dimethyl Sulfoxide
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Equivocal) 		No Activation
(Negative) 		No Activation
(Weakly Positive) 		30% RLI
(Equivocal) 		30% RLI
(Equivocal) 		30% RLI
(Negative) 		30% HLI
(Equivocal) 		30% HLI
(Negative) 		30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 118 5.5 134 10.5 110 5 128 .6 121 3.3 171 3.8 114 5.8 130 2.4 155 4.7 
3.3       
 108 4.7 
10         
 115 6.9 127 3.5 108 3.4 
33         
 134 2.6 100 5.3 125 9.3 119 6.3 125 8.1 
100         
 156 7 105 4 150 9.2 139 7.8 125 12.9 185 4.3 130 4.1 138 10.4 143 9.9 
200         
 5 s 3.3 188 16.2 
250         
 0 s 0 
333         
 102 s 2.5 153 2.1 139 5.2 188 17.6 122 4.2 137 9.3 151 3 
667         
 t 147 7.2 193 2.6 146 5.4 152 12 
850         
 205 3.5 151 12.1 
1000         
 179 6.1 183 2 197 11.7 168 9.3 140 1.7 145 6.4 
1500         
 t t 
2000         
 t 34 s 31
Positive Control 489 6.8 522 11.6 661 21.9 1111 15.7 1194 71.7 1584 64.8 597 18.3 737 24.5 776 25.4

Strain: TA1538
Dose No Activation
(Positive) 		No Activation
(Positive) 		30% RLI
(Positive) 		30% RLI
(Positive) 		30% HLI
(Positive) 		30% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 14 2.8 17 .7 20 3.5 25 3.7 21 1.8 24 .9 
3.3       
 17 1.5 
10         
 23 2.7 30 .9 
33         
 30 1 56 1 
100         
 51 1.7 84 5.2 30 2 35 3 31 3.8 33 3.2 
200         
 71 3 68 s 5.1 
250         
 6 s 6.3 
333         
 58 9 69 8.3 59 3.2 64 2.3 
667         
 89 6.2 99 2.9 91 4.9 112 2.2 
850         
 150 3.8 135 5.5 
1000         
 119 3.4 130 4.8 113 1.3 162 6.4 
1500         
 t t
Positive Control 389 15 355 8.3 587 15.4 434 26.1 637 57.3 514 11.9

Strain: TA98
Dose No Activation
(Positive) 		No Activation
(Positive) 		30% RLI
(Equivocal) 		30% RLI
(Equivocal) 		30% HLI
(Equivocal) 		30% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 16 2.1 20 2.5 35 4.5 33 2.8 24 .3 34 2.1 
3.3       
 23 4.1 
10         
 20 3 26 .7 36 5.9 30 5.1 
33         
 35 2.2 38 2.6 39 3.8 34 3.8 16 4.4 41 3.5 
100         
 52 2.3 75 5 36 3.4 41 5.2 27 5.2 36 4.5 
333         
 20 s 10.3 t 50 5.7 45 3.5 31 4.8 50 4.3 
667         
 t 
1000         
 67 4.1 91 4 68 3.8 96 1.2 
2000         
 t 13 s 1.5
Positive Control 268 31.5 479 13 347 15.6 369 13.4 503 32.7 345 11.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;