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Study Information
Study Attribute Value
CEBS Accession Number: 002-01370-0004-0000-7
Chemical Name: 2-Nitroethanol
CASRN: 625-48-9
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: G625489B
Vehicle Control: Dimethyl Sulfoxide
Study Result: Weakly Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Positive) 		10% RLI
(Negative) 		10% RLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 108 1.5 76 8.4 84 6.2 112 11.6 
12.5       
 111 4 98 1.5 95 4.9 119 9.9 
50         
 110 7.6 93 6.7 92 3.7 110 4.7 
125         
 119 4.9 97 4.3 81 5.7 107 7.2 
500         
 155 13.9 117 3.2 88 6 114 4.4 
1000         
 93 17.7 155 18 85 2 107 8 
1500         
 t t 104 1.7 99 7.9
Positive Control 704 58.4 476 25.2 1097 234.5 2270 67.9

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		10% RLI
(Negative) 		10% RLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 29 3.3 32 5.5 28 5.6 33 3.2 
12.5       
 19 2.2 22 3.4 29 1.7 27 .3 
50         
 18 1.5 29 4.6 32 2.1 34 2.9 
125         
 20 2 24 .9 24 1.7 25 4.2 
500         
 23 4.4 40 1.2 30 1.5 21 2.3 
1000         
 4 2.6 t 23 1.5 26 3.8 
1500         
 t t 29 4.4 26 2.4
Positive Control 722 130.3 891 306.3 1242 67.1 874 30.1

Strain: eColi pKM101
Dose No Activation
(Weakly Positive) 		No Activation
(Weakly Positive) 		10% RLI
(Negative) 		10% RLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 146 11.9 132 12.6 176 13.9 181 8.7 
12.5       
 143 10 166 7.1 
50         
 136 12.4 135 1.9 177 9.9 169 3.2 
125         
 146 3.7 155 3.7 191 8.3 150 10.3 
500         
 173 7 144 16.6 167 8.3 189 21.9 
1000         
 185 10.8 187 13.9 171 5.8 194 11.6 
1500         
 207 9.6 229 9.9 187 11 195 7.8 
3000         
 t 189 27.1
Positive Control 1097 93.4 898 20.2 946 4.7 1230 57.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;