Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01403-0001-0000-1
Chemical Name:	3,4-Dichlorophenol
CASRN:	95-77-2
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	190129
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	103	9	97	3.8	84	5.8	88	7.4	92	2.6	86	3.5
2	100	4.4	102	4.7	101	12.5	86	5.9	102	7.2	84	4
7	85	7.6	85	7.5	105	12.7	98	5.8	90	3.2	82	4.3
21	87	6.9	96	5.5	101	6.3	81	4.1	92	3.8	94	3.9
67	94	9	90	3.9	108	4.4	86	2.8	75	2.6	91	6.2
200	t		t		82	9.4	66	2.3	69 s	1.5	81	3.1
Positive Control	1972	47.7	1265	21.3	2634	68.3	1961	17.3	3285	44.8	2502	52.4

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	16	1.7	14	2.2	9	1.7	7	1	17	2.4	6	1
2	18	6	10	1.2	11	2.2	9	1.7	15	1.2	7	.3
7	16	1.8	12	2.3	10	1.2	8	1.7	16	0	5	.9
21	16	1.5	11	1.2	7	.3	7	.9	18	2.3	9	1.2
67	15	2.3	11	1.9	10	1.5	10	2.3	21	3.5	6	0
200	5 s	1.7	t		6	1.2	4	.6	7 s	1	3	1
Positive Control	1268	52.3	1084	25.9	179	10.4	123	16.5	228	21.5	160	11.1

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	1.2	4	.7	8	.9	4	.9	7	2.3	7	.6
2	3	.6	6	1	5	.3	2	.6	7	1.2	5	.7
7	5	.3	6	1.5	8	0	5	.6	6	1.2	5	.9
21	6	.7	3	.3	7	1.2	7	.7	5	1.5	5	2
67	6	1.2	5	.6	7	2.4	6	2.4	5	1.9	8	1.3
200	t		t		6	1.2	3	.6	7	1.3	4	.6
Positive Control	332	47.4	276	15.9	139	13.7	57	5.5	208	25.3	132	4.9

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	24	3.2	19	2	22	2.3	19	2.6	19	2.6	22	0	20	3.8
2	18	2.6	14	2	23	5.2	17	3.8	17	3.8	19	1.5	15	1.7
7	18	6.4	15	2.3	22	.6	19	2	19	2	25	.6	14	2
21	20	2.7	15	2.1	24	1.5	18	2.5	18	2.5	25	4.2	19	2.5
67	16	.7	12	1.5	28	.6	23	1.5	23	1.5	19	3.5	16	2.3
200	5	2.9	3	1.7	24	.9	16	.3	16	.3	5 s	3	16	1
Positive Control	1984	78.6	2062	152.1	2597	76.7	1790	23.8	1791	23.9	3170	27	2455	198

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;