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Study Information
Study Attribute Value
CEBS Accession Number: 002-01508-0001-0000-7
Chemical Name: 4-Methyl-3-nitroaniline
CASRN: 119-32-4
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 298179
Vehicle Control: Dimethyl Sulfoxide
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		30% RLI
(Positive) 		30% RLI
(Positive) 		30% HLI
(Positive) 		30% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 104 4.8 123 5.2 89 1.8 111 9.4 99 3.8 
33         
 107 6.4 122 4.7 93 2.1 138 8.1 138 4.6 
100         
 104 4.2 160 13.3 121 2 207 15.7 174 13.8 
333         
 106 5.8 165 1.9 150 5 472 20.8 409 28.6 
1000         
 110 s 4 262 23.1 237 s 1.2 1184 41.2 1464 s 67.5 
2000         
 92 s 19.7 335 s 33.4 62 s 62 1963 s 183.3 1726 s 20.6
Positive Control 298 10.5 305 26.4 267 9 475 30.5 324 20.9

Strain: TA98
Dose No Activation
(Equivocal) 		No Activation
(Positive) 		30% RLI
(Positive) 		30% RLI
(Positive) 		30% HLI
(Positive) 		30% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 16 1.8 15 1.5 23 .6 16 2.1 19 1.5 18 .3 
33         
 18 2.2 16 .9 33 3 24 3 29 5.1 38 2.7 
100         
 14 2.2 18 2.4 32 4.4 29 2 40 2.5 35 3.5 
333         
 24 1.5 32 2.5 47 2.2 51 3.1 89 4.2 106 12.4 
1000         
 30 s 4.4 55 s 7.4 91 8.1 99 s 3.8 370 28.3 479 s 15.3 
2000         
 7 s 4.1 26 s 13.1 116 s 7.2 110 s 5.5 1179 s 36 791 s 67.5
Positive Control 159 8.7 205 14.6 97 6.4 73 3.2 137 11.3 66 1.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;