Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01536-0004-0000-1
Chemical Name:	5-Azacytidine
CASRN:	320-67-2
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	440974
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Positive

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Positive)		No Activation (Positive)		30% RLI (Positive)		30% RLI (Weakly Positive)		30% HLI (Positive)		30% HLI (Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	114	6.2	152	7.6	158	8	147	2.7	125	8.3	147	3.5
0.3					271	13.3
1			161	3.9	341	23.7	205	11.6	171	15	206	22.2
3	157	7.1	194	3.8	358	6.7	217	14.3	228	9.3	257	17.7
10	197	17.8	232	8.8	402	4.5	245	14.2	244	6.4	266	4
16	206	2.7	291	4.5
33	306	3.8	379	16.5	252	55.8	279	4.1	402	19.4	496	28.4
66	230	6.2					206	24.9	382	29.4	365	13.5
Positive Control	366	12.7	497	34.6	380	11	499	9.4	608	15.7	627	6.9

Strain: TA98
Dose	No Activation (Negative)		5% RLI (Negative)		5% HLI (Negative)		30% RLI (Negative)		30% RLI (Negative)		30% HLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	24	1.3	28	3.1	33	4.2	35	4.5	40	3.8	33	2.3	30	2.6	28	4.1	33	2.4
1			28	5.2	41	2.3	39	1.9	41	2.9	32	.3	27	4.3	27	3	37	1.2
3	22	.9	31	2.3	39	4.1	36	2.6	35	4.7	29	1.3	32	5.8	37	2.9	37	3.8
10	28	3.5	37	2.9	38	2.9	44	.7	36	2.6	37	.7	31	3.4	31	6.1	38	1.9
16	29	6.1
33	26	.6	35	2.4	54	1.2	55	5.5	35	3.8	49	1.8	46	7.6	36	8	60	6.9
66	17	6.2	9	2.3	6	.6	45	1.5	30	1.5	54	6.4	32	12.8	13	1.3	33	4.7
Positive Control	944	27.2	469	34.8	1050	107.1	143	17	127	8.1	283	24.5	478	20.5	255	24.2	618	42.1

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;