Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01615-0028-0000-5
Chemical Name:	Aflatoxin-B1
CASRN:	1162-65-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	000003
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Positive

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	10% RLI (Positive)		10% RLI (Positive)
Protocol	Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM
0	131	4
0.001	159	11.5
0.002	172	1.9
0.003	214	19.1
0.006	270	16
0.018	566	1.5
0.032	743	19.5
0.056			782 s	74.3
0.01	544	7.4
0	131	4
0.1			421 s	36.9
Positive Control	1164	37.7	1164	37.7

Strain: TA98
Dose	10% RLI (Positive)		10% RLI (Positive)
Protocol	Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM
0	28	2.4
0.001	35	2.4
0.002	42	3.8
0.003	59	2.6
0.006	69	5.2
0.018	159	21.3
0.032	253	17.1
0.056			521	29.7
0.01	131	11.7
0	28	2.4
0.1			1134	52.3
Positive Control	823	33.7	823	33.7

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;