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Study Information
Study Attribute Value
CEBS Accession Number: 002-01640-0001-0000-4
Chemical Name: Aloe vera charcoal filtered whole leaf extract
CASRN: ALOEVFILTER
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: G03042
Vehicle Control: Distilled Water
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		10% RLI
(Negative) 		10% RLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 104 1.3 93 10.6 101 5.6 99 2.6 
50         
 114 2.7 98 4 
100         
 119 10.2 136 2 
125         
 100 2.4 98 6.8 
500         
 110 3.6 102 3.4 96 2.8 109 1.5 
1000         
 115 6.9 98 3 114 6.7 119 14.8 
3000         
 105 9.3 113 7.8 117 11.7 109 5.7 
6000         
 143 36.6 99 .9 106 4.7 98 6.6
Positive Control 750 38 663 11 2267 48.1 732 21.4

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Positive) 		10% RLI
(Negative) 		10% RLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 21 5.8 21 2 23 1.8 26 .3 27 1.3 42 9 
50         
 21 1.5 25 3.9 24 3.7 35 2.9 
100         
 41 6.2 62 2.4 
125         
 19 1 13 1.7 21 1.8 23 6 
500         
 26 6.6 19 2.2 22 3.8 45 10.2 23 2.9 50 7.9 
1000         
 32 3.1 25 .3 25 1.3 39 5.6 26 4.6 44 5.8 
3000         
 24 5.5 22 3.5 22 3.5 36 7.4 28 3.8 42 1.2 
6000         
 25 5 23 4.4 24 2.1 67 4.7 30 1.9 48 11.6
Positive Control 617 44.2 684 27.8 752 46 625 64.8 1667 50 743 31.7

Strain: eColi pKM101
Dose No Activation
(Negative) 		No Activation
(Negative) 		10% RLI
(Negative) 		10% RLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 177 11.1 145 11.5 212 2 194 17.8 
50         
 141 14.2 172 3.2 
100         
 187 14.1 216 11.1 
125         
 149 6.7 181 18 
500         
 174 14.3 140 5.1 177 2.4 206 3.8 
1000         
 180 5.8 160 8.7 195 4.7 199 1.8 
3000         
 200 8.2 159 4.8 193 10.3 212 2 
6000         
 196 3.6 178 6 205 6.1 200 7.8
Positive Control 3575 65.9 1233 19.1 1605 252 793 65.1

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;