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Study Information
Study Attribute Value
CEBS Accession Number: 002-01649-0002-0000-4
Chemical Name: Amsco solvent F
CASRN: 142582-74-9
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 994098
Vehicle Control: Acetone
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 111 11.3 155 6 120 12.2 130 13.2 133 9.3 116 9 
 0.3       
 155 6.6 
1         
 120 4.5 162 8.5 
3         
 129 5.2 150 5.5 
10         
 131 4.4 122 11.2 
33         
 111 10.5 61 s 32 
66         
 65 s 5.8 
100         
 145 7.1 143 8.1 124 5.5 128 7.8 
333         
 158 3 117 17.2 138 7.8 116 13.1 
1000         
 151 4 149 17.9 139 2.3 101 13.1 
3333         
 126 3.2 142 5.8 136 5.4 116 7 
10000         
 130 6.9 75 37.6 147 4.2 88 11.9
Positive Control 421 20.3 499 40.8 496 20.4 530 22.9 457 13 945 12

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 25 1.8 24 1.2 12 .9 9 2.2 11 2.5 11 .6 
 0.3       
 25 .9 
1         
 21 2.1 25 1.8 
3         
 19 1.2 23 2.7 
10         
 15 1.5 21 2.6 
33         
 18 4 21 1.8 
66         
 16 1 
100         
 10 2.7 9 2 13 1.2 9 1.3 
333         
 9 2.4 10 1.7 11 2.2 9 4.7 
1000         
 12 1 8 2.1 11 1.7 10 1.2 
3333         
 5 1.9 8 1.2 13 2.3 10 1.7 
10000         
 12 1.2 12 1.5 12 1.3 8 1.2
Positive Control 479 19.4 350 3.2 93 3.5 434 24.6 144 9.7 216 9.7

Strain: TA1537
Dose No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 7 .3 6 .9 10 1.2 
1         
 9 .9 
3         
 7 1.5 
10         
 9 1.5 
33         
 8 1.2 
66         
 6 s 1.8 
100         
 7 1.3 9 .3 
333         
 7 .7 5 1.2 
1000         
 7 1.8 4 .7 
3333         
 7 1.2 11 1 
10000         
 14 .7 9 .9
Positive Control 474 36.1 55 3.2 55 6.8

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 157 24.6 165 17.4 188 4.4 178 5.5 175 14.3 143 5.4 
 0.3       
 176 11 
1         
 145 2.4 189 7.3 
3         
 190 9.6 191 4.3 
10         
 192 4.9 172 10.7 
33         
 135 7.3 162 12.9 
66         
 81 s 15 
100         
 188 10.2 164 6.4 167 13.2 175 11.6 
333         
 194 3.8 165 1.2 200 8.4 148 5.8 
1000         
 178 11.7 155 9.5 200 .9 170 9.3 
3333         
 183 8.4 154 25.7 173 6.7 158 16.5 
10000         
 188 10.2 116 30.3 164 11.7 174 .6
Positive Control 699 64.1 1328 76.9 409 10.1 358 13.6 441 13.7 634 13.5

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 17 1.5 15 3.2 40 2.1 27 1.5 24 2.1 36 4.2 
 0.3       
 14 .9 
1         
 16 1.3 17 2 
3         
 20 3.5 17 1.9 
10         
 17 1.9 16 1.2 
33         
 16 .6 17 1.5 
66         
 10 .9 
100         
 34 3 21 1 24 4 32 3.7 
333         
 37 2.4 26 6 24 2.7 25 5.7 
1000         
 40 1.8 26 5.8 28 .9 34 4.2 
3333         
 30 1.2 35 4.6 33 3.5 33 3.5 
10000         
 28 13.9 37 2.9 36 4.5 40 4.8
Positive Control 441 22 431 6.4 138 7.6 363 21.5 263 7.2 688 17.6

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;