Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01740-0005-0000-9
Chemical Name:	Bromochloroacetic acid
CASRN:	5589-96-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	A34210
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Positive

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Positive)		10% RLI (Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	165	5.5	168	1.5	149	12.8	146	24.8
10	174	6.1	154	1.5
50	193	4.6	193	13.1
100	174	14.3	182	5.3
250	156	7.7	152	14.6
500	54	5.9	58	5.4
1000					216	4.5	236	7.9
2500					318	18.4	318	12.1
5000					331	7.7	330	10.7
7500					205	3.8	234	7
10000					15	4.3	5	3.3
Positive Control	621	18.5	558	7	449	30.4	367	7.5

Strain: eColi pKM101
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Equivocal)		10% RLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	293	5.8	278	6.1	265	8.5	278	13.6
10	312	10.9	308	6.9
50	284	3.8	286	7.9
100	281	2.1	277	6.7
250	315	5	312	3.5
500	76	4.7	75	4.9
1000					304	4.9	291	13.6
2500					355	12.9	315	3.4
5000					305	10.9	358	13.3
7500					304	5.6	281	40.5
10000					34	11.3	2	.6
Positive Control	869	10.7	873	2	612	20.1	554	16.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;