Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01814-0003-0000-9
Chemical Name:	C.I. Vat brown 3
CASRN:	131-92-0
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	843985
Vehicle Control:	Water
Study Result:	Negative

View Study Details | View Protocol | Download To Excel | View Summary Data | View Detailed Data

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	111	6.8	103	7.5	127	9.8	110	9.5	104	9.5	115	7.9
100	116	9.1	87	10.8	98	10.2	71	28.2	103	8.5	87	6.7
333	94	9.9	84	2.7	110	5.2	84	25.8	115	11.3	94	1.2
1000	98	14.8	95	3.8	136	3.5	88	26	134	5.2	108	3.2
3333	109	4.1	79	2.6	111	7.7	73	28.5	125	6.6	101	11.6
10000	111	13	70	6.7	88	3.7	54	19.3	117	12.7	79	3.3
Positive Control	287	7.3	288	2	1456	35.4	491	19.1	1526	39.4	1071	51

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	31	1	19	2.9	10	2.7	6	0	6	.3	7	.7
100	19	3	14	.6	8	2.3	8	.3	8	3.8	7	2.3
333	22	4.4	16	.9	8	.6	6	.3	8	.3	11	1.5
1000	28	1.2	17	1	7	.7	7	.3	9	1.5	11	2.8
3333	32	2	28	2.6	8	2.7	8	1.3	8	.6	10	2
10000	26	3.2	16	2.2	10	1.9	10	1.9	10	.3	4	2
Positive Control	327	8.2	282	15	444	25.2	136	10.9	512	24.7	331	20.1

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	5	.3	4	1.3	7	.9	8	.9	6	.6	5	0
100	6	1.3	7	1.2	6	2.3	8	2.2	7	.6	8	2.6
333	6	.6	5	.6	7	1.5	10	1.5	8	1.5	7	.7
1000	7	.6	4	0	9	1.3	12	1.3	7	1.2	7	2.2
3333	7	.3	6	1.2	9	0	10	1.2	8	1.2	8	.3
10000	6	0	7	1.2	7	1.5	5	1.5	6	.9	5	1.8
Positive Control	161	18.4	178	49.6	423	21.2	141	12.3	473	6.7	224	47.5

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	14	1.9	15	.6	27	3.5	20	1.9	25	2.9	29	4.6
100	15	1.5	15	1.2	22	5.7	30	7.5	26	3.6	30	3.8
333	19	3.5	17	.7	26	5.5	33	3.5	30	2.5	29	2.3
1000	16	.3	20	2.3	34	3.6	34	2.7	32	3.2	36	4.4
3333	19	.7	16	1.8	24	2	21	1.8	29	1.8	26	3.5
10000	13	1	15	1.2	21	5.5	18	3.9	26	5.4	14	3
Positive Control	340	20	300	21.9	1195	37.4	465	14.7	1364	70.3	926	57.1

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;