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Study Information
Study Attribute Value
CEBS Accession Number: 002-01900-0005-0000-7
Chemical Name: Coconut oil acid diethanolamine condensate
CASRN: 68603-42-9
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A44271
Strain and Species: B6C3F1 Mouse
Study Result: Male: Positive; Female: Positive

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1992-02-12 0 hour Female Slide Scoring Dermal Dermal x 66, 92 day
  Dose
(mg/kg)		 Animal
Number		 Normochromatic Erythrocytes
Trend P: 0.001
No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Ethanol 
 0         
 061 2000 3 94.5 1.5 
 0         
 062 2000 2 91.5 1.0 
 0         
 063 2000 3 92.0 1.5 
 0         
 064 2000 3 91.5 1.5 
 0         
 065 2000 3 93.0 1.5
Average ± SEM   92.500 ± 0.570 1.400 ± 0.100
 
Test Chemical Coconut oil acid diethanolamine condensate 
50         
 071 2000 3 94.0 1.5 
50         
 072 2000 4 91.5 2.0 
50         
 073 2000 3 91.0 1.5 
50         
 074 2000 2 93.5 1.0 
50         
 075 2000 5 94.5 2.5
Average ± SEM   92.900 ± 0.700 1.700 ± 0.250
Pairwise P   0.295
 
Test Chemical Coconut oil acid diethanolamine condensate 
100         
 081 2000 5 94.5 2.5 
100         
 082 2000 4 93.0 2.0 
100         
 083 2000 6 92.0 3.0 
100         
 084 2000 4 95.0 2.0 
100         
 085 2000 3 92.5 1.5
Average ± SEM   93.400 ± 0.580 2.200 ± 0.250
Pairwise P   0.091
 
Test Chemical Coconut oil acid diethanolamine condensate 
200         
 091 2000 3 95.0 1.5 
200         
 092 2000 6 94.0 3.0 
200         
 093 2000 4 91.5 2.0 
200         
 094 2000 3 93.0 1.5 
200         
 095 2000 7 93.5 3.5
Average ± SEM   93.400 ± 0.580 2.300 ± 0.410
Pairwise P   0.069
 
Test Chemical Coconut oil acid diethanolamine condensate 
400         
 101 2000 3 95.0 1.5 
400         
 102 2000 6 93.5 3.0 
400         
 103 2000 6 92.5 3.0 
400         
 104 2000 3 94.0 1.5 
400         
 105 2000 3 93.5 1.5
Average ± SEM   93.700 ± 0.410 2.100 ± 0.370
Pairwise P   0.118
 
Test Chemical Coconut oil acid diethanolamine condensate 
800         
 111 2000 6 93.5 3.0 
800         
 112 2000 8 94.5 4.0 
800         
 113 2000 7 93.5 3.5 
800         
 114 2000 7 95.5 3.5 
800         
 115 2000 6 91.5 3.0
Average ± SEM   93.700 ± 0.660 3.400 ± 0.190
Pairwise P   0.002
 

Blood

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1992-02-12 0 hour Male Slide Scoring Dermal Dermal x 66, 92 day
  Dose
(mg/kg)		 Animal
Number		 Normochromatic Erythrocytes
Trend P: 0.015
No. Examined Total MN Cells Percent NCE MN Cells
per 1000
Vehicle Control Ethanol 
 0         
 001 2000 6 94.5 3.0 
 0         
 002 2000 3 91.0 1.5 
 0         
 003 2000 1 92.0 0.5 
 0         
 004 2000 3 93.5 1.5 
 0         
 005 2000 3 92.0 1.5
Average ± SEM   92.600 ± 0.620 1.600 ± 0.400
 
Test Chemical Coconut oil acid diethanolamine condensate 
50         
 011 2000 4 92.5 2.0 
50         
 012 2000 6 93.0 3.0 
50         
 013 2000 5 96.0 2.5 
50         
 014 2000 5 94.0 2.5 
50         
 015 2000 3 90.5 1.5
Average ± SEM   93.200 ± 0.900 2.300 ± 0.250
Pairwise P   0.131
 
Test Chemical Coconut oil acid diethanolamine condensate 
100         
 021 2000 5 91.0 2.5 
100         
 022 2000 9 94.0 4.5 
100         
 023 2000 4 93.5 2.0 
100         
 024 2000 6 91.5 3.0 
100         
 025 2000 5 92.5 2.5
Average ± SEM   92.500 ± 0.570 2.900 ± 0.430
Pairwise P   0.026
 
Test Chemical Coconut oil acid diethanolamine condensate 
200         
 031 2000 2 91.5 1.0 
200         
 032 2000 8 92.5 4.0 
200         
 033 2000 6 92.5 3.0 
200         
 034 2000 5 94.0 2.5 
200         
 035 2000 9 94.0 4.5
Average ± SEM   92.900 ± 0.480 3.000 ± 0.610
Pairwise P   0.019
 
Test Chemical Coconut oil acid diethanolamine condensate 
400         
 041 2000 6 93.0 3.0 
400         
 042 2000 4 91.5 2.0 
400         
 043 2000 6 92.5 3.0 
400         
 044 2000 5 94.0 2.5 
400         
 045 2000 6 92.0 3.0
Average ± SEM   92.600 ± 0.430 2.700 ± 0.200
Pairwise P   0.047
 
Test Chemical Coconut oil acid diethanolamine condensate 
800         
 051 2000 4 92.5 2.0 
800         
 052 2000 7 95.0 3.5 
800         
 053 2000 7 94.5 3.5 
800         
 054 2000 8 93.0 4.0 
800         
 055 2000 9 95.0 4.5
Average ± SEM   94.000 ± 0.520 3.500 ± 0.420
Pairwise P   0.004