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Study Information
Study Attribute Value
CEBS Accession Number: 002-01900-0006-0000-8
Chemical Name: Coconut oil acid diethanolamine condensate
CASRN: 68603-42-9
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 104376
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 118 4.3 171 7.2 168 10.5 145 9.2 103 4.1 101 2.9 
 0.1       
 101 1.5 170 8.5 
 0.3       
 111 3.8 144 12.2 
1         
 91 5 131 6.8 
3.3       
 97 5.8 125 5.2 163 17.9 160 2.5 86 7.5 87 3.1 
6.7       
 91 3 133 3.5 
10         
 151 11.8 152 5.5 90 4.6 85 5.8 
33         
 162 6.6 163 3.2 86 7.8 88 10.8 
100         
 166 2.5 172 5.7 82 3.7 68 3.5 
200         
 128 6.6 130 3.8 22 s 5.2 41 s 3.9
Positive Control 1302 33.1 314 8.2 564 29.3 372 10.2 2232 41.5 1286 23.1

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 31 4.4 46 6.2 40 2.8 34 1.2 14 1.8 13 1.5 
 0.1       
 31 .6 51 2.3 
 0.3       
 25 1 47 5.2 
1         
 32 2.1 39 2.9 
3.3       
 28 3.7 43 2.8 31 3.8 34 4.2 13 2.6 11 3.2 
6.7       
 25 s 1.5 37 3.5 
10         
 35 2 40 3.8 8 1.3 10 3 
33         
 42 2.1 35 3.2 9 1.9 9 1 
100         
 36 2.8 39 .9 9 1.5 9 1.5 
200         
 29 5.3 33 3.7 4 .9 8 .7
Positive Control 876 38.5 123 9.8 116 9.4 102 5 104 8.3 82 4.6

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 104 4.4 81 1.5 219 6.8 217 17.7 108 3 72 4.9 103 9 
 0.1       
 100 1.7 90 .9 
 0.3       
 115 9.2 90 2.5 
1         
 114 .7 91 8 
3.3       
 115 11.5 100 6.8 201 8.7 194 5.9 101 1.5 81 2.3 104 3.2 
6.7       
 112 7.9 73 7.5 
10         
 216 9.1 174 1.7 108 3.8 72 14.2 99 8.4 
33         
 255 2.3 204 8.8 101 12.9 68 1.3 98 2.9 
100         
 225 10.7 214 2.3 104 9 24 5.4 87 s 5.4 
200         
 172 2.3 231 17.3 115 4.3 3 s .3 2 s .7
Positive Control 909 27.3 181 7.5 460 9.2 277 6.2 238 11.9 1156 15.3 768 19.1

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 22 2.6 31 2.6 36 1.2 43 1.2 33 1.8 37 2.9 
 0.1       
 18 2.3 27 1.9 
 0.3       
 16 1.9 21 .3 
1         
 16 4.5 23 3.2 
3.3       
 18 5 26 3.3 40 1.2 38 3.8 36 4.1 37 2.3 
6.7       
 21 4.4 20 2.4 
10         
 40 5.8 39 3.5 32 1.8 30 2 
33         
 36 3.2 43 1.9 26 2.7 29 2 
100         
 43 4.4 43 2.7 30 1 37 5.3 
200         
 44 3.3 49 6.8 32 2.8 31 6
Positive Control 1981 74.7 171 12 194 9.6 103 8 1159 50 777 21

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;