Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01927-0001-0000-2
Chemical Name:	Cyclohexyl anthranilate
CASRN:	7779-16-0
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	828926
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	110	15	137	5.4	124	6.3	153	5.7	115	1.3	109	7.3
0.3	88	.7	119	8.8					121	4.9	101	5.1
1	98	7.2	116	6	152	2.5	108	8.6	113	2.4	114	8
3.3	97	2.6	118	.6	141	6.4	104	9.3	109	4.1	102	2.6
10	102	1.2	116	3.5	115	4	109	6.7	110	4.3	105	5.8
20	82 s	1.3	108 s	7.2
33					113	10.4	110	3.5	114	5	90	1.7
67					123 s	8.8	114 s	8
Positive Control	879	70.4	694	27.4	867	21	1091	33.1	1759	226.7	1324	77.3

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	42	4.7	38	3.3	14	3.3	15	1.3	33	6	41	3.8
0.3	43	2.7	30	1.9					25	5.2	36	3.5
1	40	2.3	32	2.3	11	1.5	13	3.9	35	1.5	38	4.6
3.3	45	8.1	33	1.3	11	1.8	14	2.3	28	2.6	34	9
10	38	.7	27	.6	14	2.6	12	1.8	28	.9	27	3
20	29 s	3.2	25 s	2.8
33					14	2.7	11	1.5	20	.3	26 s	2.2
67					14 s	2	13 s	1.2
Positive Control	808	47.4	931	7.5	122	4.7	160	7.2	122	6.1	121	7.9

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	105	8	103	2.4	171	8.9	178	4.4	130	7.3	111	6.2
0.3	88	3.5	103	3.4					129	4.7	114	10.5
1	98	4	103	6.4	154	7.2	197	14.2	126	8.4	106	4.8
3.3	95	3.2	93	6.2	189	7.9	197	2.3	125	7.4	121	3.8
10	89 s	4.9	105	4.7	173	2.5	180	4.3	120	3.8	123	4.9
20	84 s	6.7	101 s	7
33					190	1.8	186	9.5	125	8.1	121	2.3
67					170 s	4.1	179 s	2.3
Positive Control	994	62.8	839	30.2	408	21.1	698	6.5	1448	36.9	959	23.8

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	18	.6	19	.9	39	.6	29	2.4	32	4.5	23	3.8
0.3	14	4.5	22	1.2					31	.9	25	3.5
1	14	2.3	20	2.7	35	.6	31	4.8	28	3.9	29	3.4
3.3	17	5.4	16	1.5	33	1.5	30	5.2	34	1.5	25	2.3
10	17	1.7	15	.9	33	1.2	33	4.1	34	5.6	23	2.4
20	14 s	.3	18 s	3
33					31	3.8	32	1.5	29	4.5	32	3.2
67					43 s	3	29 s	.9
Positive Control	1878	115.2	1419	19.2	394	7.3	542	30.3	1771	60.7	1154	4.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;