Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01948-0004-0000-8
Chemical Name:	D-Mannitol
CASRN:	69-65-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	315204
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	102	5.9	78	11.2	138	5.5	135	5.8	146	9.7	88	4.5
100	103	10.7	94	8.1	131	10.5	102	6.7	140	1.8	89	12.7
333	117	12.8	71	10.7	116	3.4	90	7.2	139	2	77	3.4
1000	113	5.1	79	6	121	7.1	92	7.9	139	2.5	83	.6
3333	96	4.3	72	1	126	9.1	100	6.1	121	2	81	15.2
10000	127	7.4	79	9.2	129	3.2	101	7.3	133	4.6	104	12.7
Positive Control	588	38.2	330	31.2	845	27.8	717	86.1	2630	79.1	1708	271.3

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	3	.6	5	.6	5	1	4	2	7	1.5	5	.3
100	4	.3	4	1.2	4	1.2	4	.3	4	.3	3	1.2
333	2	.9	3	.6	3	.6	7	2	6	1.5	7	1.2
1000	5	1.5	5	1.8	4	.3	4	.3	8	1.2	4	.9
3333	6	1.2	6	1.8	7	.7	6	.9	7	1.2	5	.6
10000	6	1.2	6	2.1	9	.9	7	.3	6	1.8	5	.3
Positive Control	338	14.8	134	7.5	63	1.9	56	2.9	80	5.1	48	4.9

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	3	.3	8	2.2	5	1.8	12	3	7	1.7	10	1.5
100	5	.3			10	2.2			7	.5
333	4	1.2			8	1			6	.9
1000	4	.3	4	1	10	2	18	.9	5	.3	5	1.5
1667			4	.9			16	3			8	1.5
3333	5	1.3	5	.3	12	1.2	20	2.7	5	2	6	1
6667			4	1.2			17	3.8			8	1.8
10000	6	.6	3	2.1	12	1.2	16	4.2	13	1.8	8	1.9
Positive Control	250	5.6	788	169	68	8	121	4.1	187	7.3	675	15.3

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	15	2.6	12	2	27	1.8	26	2.3	22	.6	19	2.1
100	19	1.7	14	1	28	4.6	23	2.2	20	.7	16	.7
333	20	6	15	1.8	20	4.6	19	1.5	23	4.4	18	1.5
1000	16	2.3	11	.6	22	4	24	2.8	27	4.4	19	1.9
3333	18	4.4	11	1.8	31	3.8	24	3.8	22	1.5	23	2.1
10000	22	.7	11	2.8	22	1.5	20	1.7	20	2	18	.9
Positive Control	297	31.5	269	21.5	585	48.9	362	25	2168	43.8	1591	75.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;