Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01948-0006-0000-0
Chemical Name:	D-Mannitol
CASRN:	69-65-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	514632
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	78	3.4	66	5.1	94	2.1	63	3.9	80	3	63	6.7
100	77	5.6	77	1.2	105	2.1	70	2.7	71	8.8	81	2.2
330	80	4	69	4.3	88	5.7	59	2.8	87	3.2	75	7
1000	72	8.2	59	3.4	89	2.2	63	6.4	74	3.6	75	2.7
3300	86	6.2	63	3.9	109	1.7	60	4.8	77	5.4	80	9.5
10000	77	1.2	69	4.5	111	7.4	76	13.9	78	4.3	73	3.7
Positive Control	2178	61.8	1439	43	1424	58.8	1320	55.2	2819	75.9	2151	60

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	14	1.2	8	.9	10	.7	7	.6	9	1.8	8	.7
100	16	4	10	1.3	10	1	6	1.9	7	.7	6	1.5
330	14	3.1	10	1.2	7	.6	10	.9	6	.7	9	.9
1000	16	.9	12	4.4	10	1.7	6	3.5	8	.9	8	.9
3300	14	2.3	10	1.9	8	.7	6	2.5	8	1.5	7	2.1
10000	18	2.4	11	2	7	1.5	8	1.5	11	1.7	7	2.7
Positive Control	1328	47.1	979	36.1	130	5	74	7.9	167	11.5	137	7.8

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	1	3	1.7	4	1	6	.9	6	.7	4	.3
100	7	1.2	3	1.8	10	.7	3	1.2	3	1.5	7	1.5
330	10	2.4	4	.7	7	2.4	6	1.2	5	0	6	.3
1000	11	2.3	6	1.2	5	.9	7	1.5	7	.7	4	.6
3300	7	.6	4	1.5	8	1.5	3	.3	4	1.9	3	.6
10000	9	2.1	5	.9	8	3.4	6	1.8	9	.6	7	.9
Positive Control	268	7.3	841	36.1	30	3.8	30	1.2	79	4.5	68	7.4

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	16	2	8	1.2	20	2.4	15	1.8	20	4	19	1.7
100	18	6.4	10	.6	21	2.9	12	1.2	25	.7	16	2.5
330	20	1.2	11	2.8	14	2	14	1.9	22	2.9	19	4.1
1000	12	1.2	11	1.2	18	1.5	11	2.1	17	1.8	13	3.2
3300	18	4.1	10	2.4	23	.7	13	1.2	20	.3	15	2.7
10000	18	5.2	11	1.8	20	2.3	15	2.6	24	2.3	15	2
Positive Control	2128	27	1774	100	1452	109	1013	25.2	2566	56.9	1387	6.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;