Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01948-0007-0000-1
Chemical Name:	D-Mannitol
CASRN:	69-65-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	527050
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	126	5	131	1.5	121	4.7	133	1.8	103	4.8	145	5.5
100	131	6.4	134	6.4	111	3.2	119	5.7	104	6.4	122	9.7
333	131	4.8	120	7.6	112	2.3	139	8.4	112	3.6	140	4.7
1000	125	5.4	135	10.1	114	3.9	129	.7	107	6.4	135	8.8
3333	121	8.1	135	.7	122	3.6	129	6	100	5.3	128	10.4
10000	120	6.9	140	2.4	102	5.5	133	4.3	101	6	118	6.5
Positive Control	2352	68.3	1718	52.2	1512	37.6	713	34.3	2323	71.9	1253	26.4

Strain: TA1535
Dose	No Activation (Equivocal)		No Activation (Equivocal)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	29	3.7	19	1.5	43	6.2	10	1.9	12	1.3	10	1.2	9	2
100	35	4.7	23	2.8			14	1.3	8	2.1	13	2.6	10	.6
333	37	2.4	30	4.7	34	3.3	12	2.3	12	1.2	8	.3	10	2
1000	29	.7	34	3.2	50	1	10	2	12	2	11	.3	6	1.8
2000					45	6.4
3333	50	2.9	28	3.5	57	4.8	11	3.7	13	.6	8	1.5	11	1.5
10000	43	3.8	30	1.3	43	4.1	9	.7	12	1.7	9	3	11	2.6
Positive Control	1571	6.5	1449	52.2	1604	61.8	137	2.7	60	2.3	191	10.3	115	7.2

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	6	2.1	5	1.7	9	.9	5	1.8	7	2.4	7	.9
100	6	.9	7	.6	8	1.3	8	1.7	10	1.2	6	1.5
333	7	.6	6	1.7	9	1	7	.7	12	1.9	9	.3
1000	8	.9	6	1.2	8	2.5	7	.9	9	1.8	8	.7
3333	7	1.8	6	1.5	10	2	11	1.7	10	1.9	8	.7
10000	6	1.2	9	.7	9	2.3	8	.6	11	2.7	10	1.9
Positive Control	363	86.6	578	110.7	81	21.3	34	9.5	241	31.9	120	22.9

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	24	2.3	19	2.1	35	1.8	29	3.7	34	3.8	27	2.4
100	16	4.7	23	2.1	28	3.6	43	5.9	31	.7	32	3.1
333	23	2.4	17	1.8	28	2.4	36	4.9	30	3.7	38	4.6
1000	18	2.2	17	3	28	2.3	29	1.9	32	2.6	41	7.7
3333	18	4	23	4.2	30	3.8	33	1.9	30	1.5	32	3.2
10000	14	2	16	1.2	29	6.1	26	2.8	27	5.5	31	4.5
Positive Control	1874	66.2	1477	87	1111	106.6	315	26.9	1398	141	885	27.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;