| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02042-0011-0000-2 |
| Chemical Name: | Diethylstilbestrol |
| CASRN: | 56-53-1 |
| NTP Study Type: | Genetic Toxicology - Micronucleus |
| NTP Study ID: | A06412 |
| Strain and Species: | FVB/N Mouse |
| Study Result: | Male: Negative; Female: Negative |
Blood
| Start Date | Sample Collection Time | Sex | Methodology Used | Route | Dosing Regimen |
|---|---|---|---|---|---|
| 2000-04-19 | 24 hour | Female | Slide Scoring | Gavage | Gavage x 52, 26 week |
| Dose (ug/kg) |
Animal Number |
Normochromatic Erythrocytes Trend P: 0.552 |
|||||
|---|---|---|---|---|---|---|---|
| No. Examined | Total MN Cells | Percent NCE | MN Cells per 1000 |
||||
| Vehicle Control | Corn Oil | 0 |
161 | 2000 | 1 | 97.5 | 0.5 |
0 |
162 | 2000 | 5 | 98.5 | 2.5 | ||
0 |
163 | 2000 | 2 | 97.7 | 1.0 | ||
0 |
164 | 2000 | 4 | 98.6 | 2.0 | ||
0 |
165 | 2000 | 1 | 95.9 | 0.5 | ||
0 |
166 | 2000 | 1 | 98.3 | 0.5 | ||
0 |
167 | 2000 | 2 | 97.4 | 1.0 | ||
0 |
168 | 2000 | 0 | 98.3 | 0.0 | ||
0 |
169 | 2000 | 0 | 98.3 | 0.0 | ||
0 |
170 | 2000 | 4 | 98.4 | 2.0 | ||
0 |
171 | 2000 | 1 | 97.7 | 0.5 | ||
0 |
172 | 2000 | 1 | 97.9 | 0.5 | ||
0 |
173 | 2000 | 4 | 97.5 | 2.0 | ||
0 |
174 | 2000 | 4 | 97.9 | 2.0 | ||
| Average ± SEM | 97.850 ± 0.180 | 1.070 ± 0.230 | |||||
| Test Chemical | Diethylstilbestrol | 480 |
176 | 2000 | 5 | 98.4 | 2.5 |
480 |
177 | 2000 | 1 | 98.5 | 0.5 | ||
480 |
178 | 2000 | 1 | 99.2 | 0.5 | ||
480 |
179 | 2000 | 4 | 98.2 | 2.0 | ||
480 |
180 | 2000 | 2 | 97.8 | 1.0 | ||
480 |
181 | 2000 | 2 | 98.0 | 1.0 | ||
480 |
182 | 2000 | 5 | 98.1 | 2.5 | ||
480 |
183 | 2000 | 1 | 98.1 | 0.5 | ||
480 |
184 | 2000 | 2 | 98.3 | 1.0 | ||
480 |
186 | 2000 | 2 | 98.0 | 1.0 | ||
480 |
187 | 2000 | 1 | 97.9 | 0.5 | ||
480 |
188 | 2000 | 1 | 97.6 | 0.5 | ||
480 |
189 | 2000 | 2 | 97.8 | 1.0 | ||
480 |
190 | 2000 | 0 | 97.7 | 0.0 | ||
| Average ± SEM | 98.110 ± 0.110 | 1.040 ± 0.210 | Pairwise P | 0.552 | |||
Blood
| Start Date | Sample Collection Time | Sex | Methodology Used | Route | Dosing Regimen |
|---|---|---|---|---|---|
| 2000-04-19 | 24 hour | Male | Slide Scoring | Gavage | Gavage x 52, 26 week |
| Dose (ug/kg) |
Animal Number |
Normochromatic Erythrocytes Trend P: 0.500 |
|||||
|---|---|---|---|---|---|---|---|
| No. Examined | Total MN Cells | Percent NCE | MN Cells per 1000 |
||||
| Vehicle Control | Corn Oil | 0 |
131 | 2000 | 1 | 98.2 | 0.5 |
0 |
132 | 2000 | 2 | 98.1 | 1.0 | ||
0 |
133 | 2000 | 5 | 97.1 | 2.5 | ||
0 |
134 | 2000 | 4 | 97.3 | 2.0 | ||
0 |
135 | 2000 | 3 | 97.0 | 1.5 | ||
0 |
136 | 2000 | 1 | 97.6 | 0.5 | ||
0 |
137 | 2000 | 5 | 96.9 | 2.5 | ||
0 |
138 | 2000 | 3 | 97.5 | 1.5 | ||
0 |
139 | 2000 | 4 | 97.4 | 2.0 | ||
0 |
140 | 2000 | 1 | 97.0 | 0.5 | ||
0 |
141 | 2000 | 0 | 96.1 | 0.0 | ||
0 |
142 | 2000 | 0 | 97.6 | 0.0 | ||
0 |
143 | 2000 | 6 | 98.0 | 3.0 | ||
0 |
144 | 2000 | 3 | 97.1 | 1.5 | ||
0 |
145 | 2000 | 5 | 97.4 | 2.5 | ||
| Average ± SEM | 97.350 ± 0.140 | 1.430 ± 0.250 | |||||
| Test Chemical | Diethylstilbestrol | 480 |
146 | 2000 | 2 | 97.8 | 1.0 |
480 |
147 | 2000 | 1 | 98.1 | 0.5 | ||
480 |
148 | 2000 | 2 | 97.9 | 1.0 | ||
480 |
149 | 2000 | 2 | 98.5 | 1.0 | ||
480 |
150 | 2000 | 2 | 98.1 | 1.0 | ||
480 |
151 | 2000 | 3 | 97.2 | 1.5 | ||
480 |
152 | 2000 | 6 | 94.5 | 3.0 | ||
480 |
153 | 2000 | 1 | 97.8 | 0.5 | ||
480 |
154 | 2000 | 3 | 97.4 | 1.5 | ||
480 |
155 | 2000 | 3 | 97.6 | 1.5 | ||
480 |
156 | 2000 | 4 | 97.3 | 2.0 | ||
480 |
157 | 2000 | 5 | 98.0 | 2.5 | ||
480 |
158 | 2000 | 2 | 97.3 | 1.0 | ||
480 |
159 | 2000 | 5 | 98.0 | 2.5 | ||
480 |
160 | 2000 | 2 | 98.7 | 1.0 | ||
| Average ± SEM | 97.610 ± 0.250 | 1.430 ± 0.190 | Pairwise P | 0.500 | |||