| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02042-0013-0000-4 |
| Chemical Name: | Diethylstilbestrol |
| CASRN: | 56-53-1 |
| NTP Study Type: | Genetic Toxicology - Micronucleus |
| NTP Study ID: | A30983 |
| Strain and Species: | FVB/N Mouse |
| Study Result: | Male: Negative; Female: Negative |
Blood
| Start Date | Sample Collection Time | Sex | Methodology Used | Route | Dosing Regimen |
|---|---|---|---|---|---|
| 2000-04-15 | 24 hour | Female | Slide Scoring | Dermal | Dermal x 52, 26 week |
| Dose (ug/kg) |
Animal Number |
Normochromatic Erythrocytes Trend P: 0.388 |
|||||
|---|---|---|---|---|---|---|---|
| No. Examined | Total MN Cells | Percent NCE | MN Cells per 1000 |
||||
| Vehicle Control | Ethanol | 0 |
361 | 2000 | 4 | 97.6 | 2.0 |
0 |
362 | 2000 | 2 | 97.3 | 1.0 | ||
0 |
363 | 2000 | 2 | 98.3 | 1.0 | ||
0 |
364 | 2000 | 3 | 97.4 | 1.5 | ||
0 |
365 | 2000 | 1 | 96.5 | 0.5 | ||
0 |
366 | 2000 | 3 | 97.5 | 1.5 | ||
0 |
367 | 2000 | 4 | 97.7 | 2.0 | ||
0 |
368 | 2000 | 7 | 98.2 | 3.5 | ||
0 |
369 | 2000 | 2 | 97.5 | 1.0 | ||
0 |
370 | 2000 | 3 | 97.0 | 1.5 | ||
0 |
371 | 2000 | 6 | 97.0 | 3.0 | ||
0 |
373 | 2000 | 0 | 97.0 | 0.0 | ||
0 |
374 | 2000 | 3 | 97.3 | 1.5 | ||
0 |
375 | 2000 | 4 | 97.6 | 2.0 | ||
| Average ± SEM | 97.420 ± 0.130 | 1.570 ± 0.250 | |||||
| Test Chemical | Diethylstilbestrol | 480 |
376 | 2000 | 4 | 96.7 | 2.0 |
480 |
377 | 2000 | 4 | 97.1 | 2.0 | ||
480 |
378 | 2000 | 4 | 96.7 | 2.0 | ||
480 |
379 | 2000 | 5 | 96.8 | 2.5 | ||
480 |
380 | 2000 | 6 | 97.4 | 3.0 | ||
480 |
381 | 2000 | 3 | 99.3 | 1.5 | ||
480 |
382 | 2000 | 3 | 98.1 | 1.5 | ||
480 |
383 | 2000 | 5 | 97.5 | 2.5 | ||
480 |
384 | 2000 | 5 | 97.2 | 2.5 | ||
480 |
385 | 2000 | 0 | 98.0 | 0.0 | ||
480 |
386 | 2000 | 3 | 96.1 | 1.5 | ||
480 |
387 | 2000 | 2 | 97.8 | 1.0 | ||
480 |
388 | 2000 | 0 | 97.7 | 0.0 | ||
480 |
389 | 2000 | 4 | 98.3 | 2.0 | ||
480 |
390 | 2000 | 2 | 98.5 | 1.0 | ||
| Average ± SEM | 97.550 ± 0.210 | 1.670 ± 0.230 | Pairwise P | 0.388 | |||
Blood
| Start Date | Sample Collection Time | Sex | Methodology Used | Route | Dosing Regimen |
|---|---|---|---|---|---|
| 2000-04-15 | 24 hour | Male | Slide Scoring | Dermal | Dermal x 52, 26 week |
| Dose (ug/kg) |
Animal Number |
Normochromatic Erythrocytes Trend P: 0.662 |
|||||
|---|---|---|---|---|---|---|---|
| No. Examined | Total MN Cells | Percent NCE | MN Cells per 1000 |
||||
| Vehicle Control | Ethanol | 0 |
331 | 2000 | 2 | 97.8 | 1.0 |
0 |
332 | 2000 | 7 | 97.7 | 3.5 | ||
0 |
333 | 2000 | 3 | 96.8 | 1.5 | ||
0 |
334 | 2000 | 3 | 97.7 | 1.5 | ||
0 |
335 | 2000 | 1 | 97.5 | 0.5 | ||
0 |
336 | 2000 | 4 | 97.7 | 2.0 | ||
0 |
337 | 2000 | 3 | 98.2 | 1.5 | ||
0 |
338 | 2000 | 3 | 97.3 | 1.5 | ||
0 |
339 | 2000 | 1 | 97.9 | 0.5 | ||
0 |
340 | 2000 | 3 | 98.3 | 1.5 | ||
0 |
341 | 2000 | 3 | 97.8 | 1.5 | ||
0 |
342 | 2000 | 5 | 96.8 | 2.5 | ||
0 |
343 | 2000 | 3 | 97.8 | 1.5 | ||
0 |
344 | 2000 | 3 | 98.3 | 1.5 | ||
0 |
345 | 2000 | 4 | 97.2 | 2.0 | ||
| Average ± SEM | 97.650 ± 0.120 | 1.600 ± 0.190 | |||||
| Test Chemical | Diethylstilbestrol | 480 |
346 | 2000 | 1 | 97.8 | 0.5 |
480 |
347 | 2000 | 3 | 95.8 | 1.5 | ||
480 |
348 | 2000 | 3 | 96.9 | 1.5 | ||
480 |
350 | 2000 | 0 | 97.0 | 0.0 | ||
480 |
353 | 2000 | 3 | 95.9 | 1.5 | ||
480 |
354 | 2000 | 1 | 96.6 | 0.5 | ||
480 |
355 | 2000 | 4 | 95.5 | 2.0 | ||
480 |
357 | 2000 | 6 | 96.6 | 3.0 | ||
480 |
358 | 2000 | 6 | 97.4 | 3.0 | ||
480 |
359 | 2000 | 2 | 99.3 | 1.0 | ||
480 |
360 | 2000 | 3 | 97.4 | 1.5 | ||
| Average ± SEM | 96.930 ± 0.320 | 1.450 ± 0.290 | Pairwise P | 0.662 | |||