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Study Information
Study Attribute Value
CEBS Accession Number: 002-02042-0017-0000-8
Chemical Name: Diethylstilbestrol
CASRN: 56-53-1
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 209298
Vehicle Control: 95% Ethanol
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 87 2.3 81 19 121 13.6 106 3.7 129 4.4 125 6.3 
 0.03      
 92 .9 
 0.1       
 81 4.8 93 4.7 
 0.3       
 100 4.5 91 5.2 108 1.9 110 2.6 
1         
 90 6.3 94 5.6 107 4.4 97 2.2 119 8.1 117 6.4 
3.3       
 75 s 3.5 74 s 1.5 98 9.3 117 2.3 126 10.5 129 3.3 
6.6       
 68 s 2.3 
10         
 101 12.9 101 5.9 113 6.8 112 5.9 
33         
 113 5.8 114 10.3 117 s 7.1 122 s 10.4 
66         
 92 s 2.3 111 s 3.7
Positive Control 1268 35.9 1096 23.1 481 22.5 1173 71.7 1124 40.8 919 29.9

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 24 3.5 22 2.6 24 2.7 19 3.5 34 3.2 34 1.5 
 0.03      
 24 1.7 
 0.1       
 19 5.4 18 4.6 
 0.3       
 19 2.3 20 1.9 22 3.5 24 2.3 
1         
 14 1.5 24 .6 23 3.4 25 2.1 36 4 34 5 
3.3       
 15 s 2 16 s 2.4 22 2.6 24 1 32 6.5 31 2.6 
6.6       
 12 s 2.3 
10         
 22 6.7 25 .9 31 6.3 37 4.3 
33         
 23 4.5 21 .3 30 s 4.4 32 s 4.4 
66         
 26 s 0 22 s 2
Positive Control 1012 16.3 1056 41.9 154 5.4 221 15.8 101 3.3 77 2

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 59 .3 106 2.9 141 4.2 134 .7 140 9.3 134 8.3 
 0.03      
 100 8.8 
 0.1       
 58 1.7 106 4.9 
 0.3       
 54 1.5 100 3.5 127 5.5 132 6.4 
1         
 53 1.2 107 5.2 116 8.3 129 6.1 120 9 128 5.2 
3.3       
 57 s 4 86 s 3.5 110 14.2 145 6.4 140 7.9 120 2.2 
6.6       
 39 s 2 
10         
 113 9.9 134 5.4 142 3.2 116 5.7 
33         
 106 8.1 135 5.8 121 s 8.1 112 s 6.2 
66         
 104 s 2.3 119 s 2.4
Positive Control 1780 104.4 739 18 432 36.3 521 26.2 936 37.6 694 4.3

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Equivocal) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 21 .9 24 .9 26 3.8 32 1.5 43 6.4 34 2.9 
 0.03      
 26 2.3 
 0.1       
 22 2.7 23 3.2 
 0.3       
 22 4 25 .9 33 2.3 35 3.7 
1         
 24 1.7 26 1.7 44 2 34 4.3 38 1.2 40 2.9 
3.3       
 19 4.7 19 s 2.1 35 2 31 1.3 42 6.4 40 2.7 
6.6       
 23 s 2 
10         
 37 4.4 34 4.4 44 3.8 38 1.5 
33         
 36 4.9 33 2.9 42 1.2 41 3.2 
66         
 42 s 4.2 34 s 2.7
Positive Control 1888 194.5 1736 91.7 412 18.9 1208 42.8 958 34.4 718 22.8

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;