Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02051-0001-0000-1
Chemical Name:	Diisononyl phthalate
CASRN:	28553-12-0
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	026376
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

View Study Details | View Protocol | Download To Excel | View Summary Data | View Detailed Data

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	112	5.8	116	7.8	114	6	114	6.9	106	2.3	135	6.9
100	112	8.5	98	10.1	120	5.6	103	11.5	121	10.6	127	1.2
333	117	2.7	84	13.1	111	1.3	92	2.4	103	8.2	97	6
1000	117	5.2	108	16.4	122	7	104	2.6	120	7.8	110	7.8
3333	104	3.5	93	18.2	104	9.7	99	4.5	109	2.3	99	14.4
10000	122 p	7.6	95	14.7	111 p	1.8	103 p	4.8	99 p	7.7	99 p	4.8
Positive Control	414	9.4	361	3.2	455	11.5	1075	61	1578	41.2	1316	178.5

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	27	3.8	35	4.6	10	2.8	9	2.3	17	1.7	16	1.5
100	33	3.3	32	3	9	3.2	8	2	16	1.5	11	2.9
333	38	9	33	1.8	10	1.2	8	2	12	3.5	11	2.3
1000	35	3	31	1.3	11	2.1	10	2.2	11	2	8	2.3
3333	35	3.7	38	2.6	8	2	10	1.5	13	2.6	8	1.9
10000	31 p	2.6	28 p	1.8	9 p	2.5	10 p	1.2	9 p	1.8	11 p	2.6
Positive Control	501	3	449	32.9	246	24.7	209	9	534	3.2	564	13

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	6	1.3	5	1.5	9	1.8	7	2.1	7	2.9	5	.7
100	5	1	4	.6	8	2.4	8	1.7	7	3	6	1.9
333	5	2	7	1.3	11	1.9	7	1.2	10	.3	5	.9
1000	5	.6	6	1.9	6	.6	5	.3	5	1.5	7	.9
3333	5	1.5	4	.9	10	2	8	0	9	1.7	8	2.3
10000	5 p	.9	6 p	2	7 p	.9	8 p	1.7	6 p	.7	7 p	1.2
Positive Control	414	93.3	181	11	127	2.1	210	1.8	287	13.7	357	66.4

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	19	2.9	20	3.5	29	5	28	.9	33	2.1	28	2.3
100	14	3.2	14	.3	29	.9	23	2.5	23	3.8	29	.7
333	18	1.7	15	3.2	27	1.7	22	4.2	31	4.4	27	1.5
1000	20	2.3	16	.3	24	3.2	25	3.2	26	2.4	25	2.3
3333	20	3.8	17	2.2	24	2.7	20	3.2	24	4.9	22	3.5
10000	15 p	3.4	15 p	1.5	26 p	3.8	25 p	5	30 p	3.1	27 p	1.2
Positive Control	818	37.7	876	40.4	427	63.3	919	31.5	1493	10.8	1543	78.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;