Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02053-0001-0000-3
Chemical Name:	Diisopropylamine
CASRN:	108-18-9
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	199477
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	97	1.7	94	7.6	147	11.2	127	8	191	6.7	170	3.7
100	90	5.8	86	6.4	143	13.7	118	12.1	176	11.7	160	8.5
333	83	1.8	88	5.5	131	13	127	7.1	179	7.8	144	13.4
1000	81	5	89	4.7	116	2.7	103	6.5	165	14.4	162	17.9
3333	74	10.4	83	.9	120	6	100	2.3	171	14.3	133	11.4
10000	73	0	67	4.3	93	1.5	87	2	81	4.1	96	2
Positive Control	1401	23.5	1244	13.4	2252	102.3	922	77.4	1832	92.9	1583	101.6

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	9	2	6	2.3	8	.9	7	1.7	10	2	19	2
33			8	0			7	1			14	1.7
100	6	0	5	.7	8	1.7	5	.6	14	1.5	18	1
333	4	1.2	9	1.7	10	.3	8	1.2	12	5.2	18	2.3
1000	4	.6	6	.3	7	1.9	5	.6	9	2	21	2.5
3333	3	1	6	.3	5	.6	2	.3	8	1.9	10	3.8
10000	0	0			t				t
Positive Control	935	131.1	107	24.2	239	8.7	123	3.7	549	85.2	129	15.8

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	.3	9	1.9	8	1.3	10	1	11	2.3	16	3.8
33			7	.6			7	1.7			12	1.5
100	3	1.2	6	.7	9	1.5	8	1.9	15	1.5	19	1.5
333	5	.3	5	1.3	7	1.2	9	.9	12	1.7	20	2.3
1000	6	.6	5	.7	7	1.7	8	.3	5	1.2	20	.6
3333	4	.3	6	.6	9	2.5	2	1	8	1.3	2	.7
10000	0	0			0	0			1	1
Positive Control	698	264.4	904	145.4	119	30.3	284	27	259	37.8	164	13.6

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	13	2.4	15	2	29	4.3	19	.9	37	6.4	30	3.2
33							13	1.5
100	18	3	8	2	30	3.9	11	2.3	39	6	32	1.2
333	15	.9	12	4.3	32	5.6	9	2.2	33	6.7	31	5.2
1000	20	1.9	11	.9	30	3.5	16	.9	41	7.5	30	2.3
3333	16	3.2	12	2.2	28	4.2	12	1.2	31	1.8	25	4.5
10000	t		0	0	0	0			0	0	0	0
Positive Control	169	13.9	166	21	1408	29.8	560	47	857	3.5	1310	172.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;