Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02061-0002-0000-3
Chemical Name:	Dimethyl glutarate
CASRN:	1119-40-0
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	A20348
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	141	28.3	137	4.6	112	6.4	112	2.6	153	5	158	5.8
100	105	3.9	141	3	92	5	113	3.5	151	21.3	165	14.9
333	110	3.8	141	7.9	116	1.5	98	13.2	162	7.5	144	4.5
1000	109	3.6	147	9.2	109	5.7	111	3.5	161	17.6	167	10.5
3333	107	3.8	137	10.7	108	5.8	105	3	149	19.2	137	9.2
10000	91	6.3	141	8.2	52	4.8	64	5	179	11.4	151	22.5
Positive Control	882	20.3	761	39.6	425	32.8	495	20.3	986	5.1	906	48.2

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	12	.3	14	1.5	12	1.5	12	.9	8	2.3	7	1
100	9	.3	14	.7	13	1.9	9	.3	10	3.8	10	2.2
333	9	.3	9	.3	10	0	12	2.3	10	1.3	12	1.7
1000	12	1.5	15	2.2	11	1	13	1.9	8	1.5	11	1.9
3333	12	1.8	10	1.9	12	1.2	16	1.5	8	1.9	10	1
10000	9	.6	17	3.5	10	.7	11	.6	8	.9	14	.6
Positive Control	830	11.6	926	16.2	165	9	190	6.6	223	7	202	6.4

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	141	7.9	131	18.9	166	6.1	189	6.4	163	4	188	7.6
100	141	3.7	152	18.2	164	8.3	181	6.8	162	10.7	187	1
333	147	10.3	141	7.5	173	9.3	176	11.7	193	3.1	186	6.1
1000	144	1	122	2.1	154	8.6	148	15.9	180	5.5	186	6.9
3333	116	4.8	136	5.5	178	12.4	189	5.5	159	.3	172	6.5
10000	123	11.1	141	10	186	3.8	133	31.8	157	20	179	6.6
Positive Control	532	14.1	622	15.1	867	76.9	987	43.3	859	25.5	740	20.6

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	14	2.9	20	3.3	22	2.8	26	2.6	23	4	27	3
100	18	3.6	18	3.8	25	1.9	31	3.2	25	6.7	24	.6
333	18	3	23	1.9	16	2.2	25	3.5	27	2	24	3.3
1000	18	3.7	18	2	21	2.6	24	4.7	24	3.6	27	.9
3333	14	1.2	16	1.5	27	.3	25	2.3	23	4.3	22	2.4
10000	14	2.5	17	4	16	1.5	23	2.7	19	2.6	21	4
Positive Control	311	3.8	513	17.7	471	26.3	481	14.9	505	14.7	692	23.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;