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Study Information
Study Attribute Value
CEBS Accession Number: 002-02062-0003-0000-5
Chemical Name: Dimethyl hydrogen phosphite
CASRN: 868-85-9
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: 224367
Strain and Species: B6C3F1 Mouse
Study Result: Male: Positive

Bone Marrow

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1989-07-25 24 hour Male Slide Scoring Intraperitoneal Injection Intraperitoneal Injection x 3, 72 hour
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.000
No. Examined Total MN Cells Percent PCE MN Cells
per 1000
Vehicle Control Phosphate Buffered Saline 
 0         
 646 2000 2 39.5 1.0 
 0         
 657 2000 1 21.0 0.5 
 0         
 668 2000 8 25.0 4.0 
 0         
 684 2000 6 37.5 3.0 
 0         
 700 2000 4 24.5 2.0
Average ± SEM   29.500 ± 3.750 2.100 ± 0.640
 
Test Chemical Dimethyl hydrogen phosphite 
250         
 649 2000 3 47.0 1.5 
250         
 909 2000 0 39.5 0.0 
250         
 912 2000 4 47.5 2.0 
250         
 914 2000 1 41.5 0.5 
250         
 935 2000 3 38.5 1.5
Average ± SEM   42.800 ± 1.880 1.100 ± 0.370
Pairwise P   0.962
 
Test Chemical Dimethyl hydrogen phosphite 
500         
 903 2000 16 33.5 8.0 
500         
 904 2000 7 24.5 3.5 
500         
 905 2000 10 27.5 5.0 
500         
 906 2000 11 40.0 5.5 
500         
 907 2000 17 27.5 8.5
Average ± SEM   30.600 ± 2.770 6.100 ± 0.940
Pairwise P   Value less than 0.0001
 
Positive Control Mitomycin-C 
 0.2       
 943 2000 6 34.5 3.0 
 0.2       
 944 2000 11 37.5 5.5 
 0.2       
 946 2000 12 44.5 6.0 
 0.2       
 947 2000 14 42.5 7.0 
 0.2       
 948 2000 15 30.0 7.5
Average ± SEM   37.800 ± 2.630 5.800 ± 0.780
Pairwise P   Value less than 0.0001
 

Bone Marrow

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1989-11-28 24 hour Male Slide Scoring Intraperitoneal Injection Intraperitoneal Injection x 3, 72 hour
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.078
No. Examined Total MN Cells Percent PCE MN Cells
per 1000
Vehicle Control Phosphate Buffered Saline 
 0         
 368 2000 3 55.0 1.5 
 0         
 423 2000 6 60.0 3.0 
 0         
 432 2000 6 55.0 3.0 
 0         
 434 2000 3 50.5 1.5 
 0         
 450 2000 9 31.0 4.5
Average ± SEM   50.300 ± 5.050 2.700 ± 0.560
 
Test Chemical Dimethyl hydrogen phosphite 
250         
 356 2000 4 50.0 2.0 
250         
 373 2000 5 48.5 2.5 
250         
 384 2000 6 37.0 3.0 
250         
 403 2000 3 27.0 1.5 
250         
 430 2000 4 46.0 2.0
Average ± SEM   41.700 ± 4.310 2.200 ± 0.250
Pairwise P   0.763
 
Test Chemical Dimethyl hydrogen phosphite 
500         
 425 0 0 0 0.0 
500         
 426 2000 7 16.5 3.5 
500         
 429 0 0 0 0.0 
500         
 431 2000 8 18.5 4.0 
500         
 433 2000 10 24.0 5.0
Average ± SEM   19.670 ± 2.240 4.170 ± 0.440
Pairwise P   0.057
 
Positive Control Mitomycin-C 
 0.2       
 363 2000 11 63.5 5.5 
 0.2       
 378 2000 7 57.0 3.5 
 0.2       
 407 2000 10 69.0 5.0 
 0.2       
 427 2000 10 50.0 5.0 
 0.2       
 443 2000 8 55.0 4.0
Average ± SEM   58.900 ± 3.330 4.600 ± 0.370
Pairwise P   0.013