Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02062-0004-0000-6
Chemical Name:	Dimethyl hydrogen phosphite
CASRN:	868-85-9
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	772334
Vehicle Control:	Water
Study Result:	Equivocal

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Equivocal)		No Activation (Equivocal)		10% RLI (Negative)		10% RLI (Weakly Positive)		10% HLI (Equivocal)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	145	10.4	149	5.4	197	8.4	188	1.9	209	3.5	223	3.5	110	6.1
100	144	13.8	152	11.5	170	4.4	188	21.9	200	7.8	177	17.9	92	3.3
333	192	12	156	9.8	186	17.7	239	11.9	223	1.5	192	15.3	112	6.2
1000	161	16.2	151	6.5	189	13.3	225	22.2	248	8.3	204	5.8	110	4.3
3333	203	6.4	179	9.6	199	5.9	268	2.4	242	11.3	197	18.2	84	13.8
10000	204	13.5	168	9.1	224	3.6	269	22.9	234	10.1	206	9.3	t
Positive Control	1882	197.2	1305	23.3	2073	71.3	1405	77.4	1014	68	3362	176.8	1919	139.9

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	19	1.7	26	3	37	5.2	32	1.5	11	1.7	27	3.6	35	5.2	13	2.2
100	22	1.8	34	3.5	29	4.1	28	2.4	10	3	27	1.8	33	2	13	2
333	25	1	33	1.9	33	2.9	26	.7	13	1.5	30	2.3	37	2.3	11	1.2
1000	16	.7	32	2.8	34	1.2	37	2.4	12	2	31	4.5	42	6.2	12	.3
3333	25	1.2	32	1.9	27	7	40	4.1	14	4.1	30	6.3	37	3.2	13	2.4
10000	19	.7	26	1.5	27	1.2	40	4.5	t		34	4.6	40	3.6	t
Positive Control	823	68.2	816	93.2	264	19.2	432	15.5	447	23.4	255	15.8	348	33	367	45.1

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	14	4.1	16	.9	22	1.3	19	1.5	21	1.8	22	3.2
100	17	2.2	14	2.2	20	2.4	27	1.9	20	1.2	27	4.3
333	17	1	13	.7	14	2.1	18	2.4	17	.6	19	2.9
1000	14	2.3	18	2.7	22	2.5	19	4.2	19	1.7	25	2.4
3333	12	1.8	14	.6	12	2.4	19	2.6	19	1.8	24	1.8
10000	10	.7	11	1.2	17	1.5	15	.9	12	1.9	17	4.2
Positive Control	195	29.9	275	84.8	99	3	142	21.1	167	11.3	281	20.8

Strain: TA98
Dose	No Activation (Equivocal)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Equivocal)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	28	3.8	31	3.2	35	10.1	55	2.7	39	2.7	35	8.6	57	5.2	43	4.2
100	27	2.5	35	2.6	33	.6	51	1.9	35	2.1	37	1.3	51	8.5	36	8.5
333	29	1.2	33	1.8	51	4.7	47	3.8	36	2.5	48	5.2	69	.5	39	4.3
1000	31	2.6	37	4.4	51	.6	52	7.2	26	6	52	3.2	48	5.2	31	3.5
3333	32	1.9	37	3.2	46	1	47	4.4	34	1.9	47	1.9	54	6.4	29	6.1
10000	40	5.5	42	5.9	56	2.3	38	6.7	t		57	4.7	42	5.5	t
Positive Control	510	6.1	228	8.6	973	71	1598	63	1125	80.5	2806	109.1	821	25.2	1213	142.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;