Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02062-0005-0000-7
Chemical Name:	Dimethyl hydrogen phosphite
CASRN:	868-85-9
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	940869
Vehicle Control:	Water
Study Result:	Weakly Positive

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Equivocal)		No Activation (Negative)		30% HLI (Equivocal)		10% RLI (Equivocal)		10% RLI (Negative)		10% HLI (Equivocal)		10% HLI (Equivocal)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	136	1.7	144	5.5	165	7.8	126	4.3	148	4	136	2.4	142	6.7
100			139	6.6			143	9.9			149	2.6
333			145	3.7			148	8.7			153	6
1000	162	2.8	156	2	155	5.8	143	9.1	153	5.8	139	2.6	147	3.5
3333	173	1.2	157	1.8	171	11.1	146	12.1	166	5.5	170	8.3	174	13.9
5000	175	6			177	15.6			170	4.4			187	11.7
7500	193	2.3			189	12.9			162	7.4			200	6.4
10000	190	2.9	172	9.8	196	9.7	156	6.6	161	7.8	190	1	193	10
Positive Control	1000	3.2	1210	14	1103	37.3	543	13.5	1430	43.1	804	24.5	1004	168

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	28	2	37	.6	13	2.2	13	2.3	12	.9	12	2.2
100	31	4.6			17	1.9			12	1.7
333	26	3			13	1			14	2.7
1000	27	2.1	31	5.8	18	.3	15	1.5	13	1.7	19	2.3
3333	26	.3	31	2.8	21	3.8	19	3.8	14	1.9	18	2.1
5000			33	2			16	2.7			17	2.4
7500			34	1.7			13	1.2			21	2.6
10000	23	3.2	33	1	18	.9	19	2.2	16	1.5	18	2.7
Positive Control	968	17.6	920	38.9	84	8.7	73	4.2	91	10.8	237	28.5

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	2.3	5	1	8	1.8	6	1.3	10	.6	8	1.8
100	7	2.2			11	1.2			9	3.2
333	7	2			8	1			9	2.6
1000	8	2.3	4	.6	11	.7	7	2	12	1.9	10	1.2
3333	8	2.4	3	.6	12	1.7	7	.9	11	.5	6	2.1
5000			7	2			7	2.2			7	1.2
7500			6	1.5			6	.6			9	.7
10000	8	.7	3	.6	6	.3	5	1.2	7	.7	9	2.3
Positive Control	223	50.4	341	49.1	60	5.5	200	14.5	86	5.6	136	16.5

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	24	5.4	19	1.9	27	3.5	31	1.7	40	3.2	30	1.2
100	21	3.4			29	3.3			32	3.7
333	16	3.2			29	2.6			30	3.8
1000	25	4.9	18	1.2	29	7.3	20	1.8	33	1.2	29	3.2
3333	21	1.9	19	2.2	29	4.1	25	3.5	29	3.8	27	4.2
5000			18	1.8			28	1.5			26	4.3
7500			17	4.8			25	1.5			26	4.1
10000	12	1.2	18	1.2	31	2.4	34	2.6	31	1.7	32	4.9
Positive Control	1304	53.2	1433	41.3	348	34.1	2011	47.5	558	21.9	1056	75.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;