Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02126-0001-0000-4
Chemical Name:	Ethanol
CASRN:	64-17-5
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	427021
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	116	8.4	91	3.7	116	3.7	130	2	106	6.7	96	4
100	105	7.4	94	1.9	123	7	125	4.7	109	2.3	112	5.7
333	124	1.2	95	7.5	120	4.5	126	6.3	107	9.3	103	9.5
1000	124	8.3	89	7	132	15.2	130	4	90	7.2	97	2.8
3333	105	3.5	94	7.4	119	1	135	12.1	92	10.1	102	2.3
10000	110	4.7	96	2.3	112	10.4	128	4.2	104	6.7	86	2.8
Positive Control	458	22.4	370	3.8	985	74.8	499	11.4	1549	28.8	920	125

Strain: TA104
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	372	8.2	304	3.3	403	15.2	405	14.6	393	9.5	408	8.1
100	391	14.1	321	9.4	441	6.1	387	13.5	371	8.4	368	29.8
333	376	27.7	260	7.5	450	20.4	419	36.2	363	20.7	360	20.1
1000	375	9	283	16.5	446	11.8	405	10.8	392	7.2	388	1.2
3333	358	29.5	275	10.5	414	22.6	413	9.1	386	6.9	324	7.5
10000	321	8.5	277	8.8	417	2.6	395	4.8	376	21.3	379	5.2
Positive Control	998	16.9	1036	37.7	1623	34.5	2202	51.6	3483	75.1	3450	37.4

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	19	2.4	13	3.5	13	3.2	13	4.1	9	1.5	11	.3
100	17	2.4	13	.3	13	2	13	3	15	.7	12	.9
333	18	3.8	14	1.2	16	2.6	10	2.7	11	3	17	2.2
1000	17	1.2	14	2.8	19	2.3	12	2.6	13	1.2	10	3.3
3333	17	1.5	11	1.7	11	0	12	2.6	13	2.7	10	2
10000	13	4.3	14	2.3	18	2.7	15	1.2	14	1.5	10	1.5
Positive Control	322	9.3	217	5.3	268	16	184	3.3	234	8.4	81	2.4

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Equivocal)		30% RLI (Negative)		30% HLI (Equivocal)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	156	18.8	103	6.8	170	12.5	98	.9	138	3.9	123	9	111	10.9	101	7
1							99	8.1			118	4.7
3.3							103	3.4			120	.6
10							94	5.8			122	3.2
33							100	4.7			106	10.7
100	127	4.9	94	2.1	214	14	85	10.4	180	17.3	150	9	127	.9	97	5.1
333	127	4.4	94	6.4	189	6	101	7.5	174	8.4	117	5.2	104	1.7	91	8.7
1000	133	15.8	105	2	220	4	92	1.5	175	10.8	127	2.8	121	7.5	98	3.5
3333	118	6.2	90	3.8	212	10.6	89	11.7	160	2.7	153	1.5	111	8.1	103	7.4
10000	165	3.1	112	1.5	192	3.5	92	6.7	158	3.2	136	5.3	104	7.9	101	1.9
Positive Control	435	9.8	301	17.3	1258	16.7	311	7.1	999	41.8	850	26.7	2236	42.4	292	2.2

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	18	2.9	14	1.5	32	4.5	22	.9	27	1.8	28	4.6
100	18	1.2	15	3.7	22	3.7	21	3.5	29	.6	31	1.7
333	19	.3	19	3	31	1	19	2	32	5.5	27	1.2
1000	17	1.8	20	3.3	23	3	26	2.3	37	1.5	19	3
3333	20	3.2	17	2.9	24	2.9	31	2.4	34	1.5	26	4
10000	18	1.3	18	1.8	26	2.2	28	.9	26	1.8	33	5.9
Positive Control	314	13.6	391	10.9	342	20.5	294	21.4	258	6.5	1947	428.4

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;