Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02156-0005-0000-1
Chemical Name:	NTP-88 diet study (EGMME)
CASRN:	109-86-4
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	057075
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	172	5.6	131	9.1	131	3.5	148	7	187	2.3	168	12.4
100	167	6.5	122	3.6	132	4.5	141	4.1	171	5.4	177	7.3
333	169	8.4	131	.9	132	5.5	128	6.6	186	3.8	164	5.2
1000	179	6.4	140	9.9	119	10.9	148	6.4	193	12.3	179	7.3
3333	171	3.1	131	6.7	123	1.5	131	6.4	168	5.5	167	5.9
10000	162	.9	129	9.7	130	5.4	127	9.5	165	1.2	155	6.1
Positive Control	382	7.9	530	29.1	1582	57.7	520	2.6	1599	52.9	1212	79.3

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% RLI (Negative)		30% HLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	23	3.2	25	3.4	11	2.1	17	3.7	12	.9	12	2.3	14	3.2	11	1.9
100	24	1.9	18	1.2	11	1.8	11	2.4	13	1.5	12	.9	9	1.2	8	1.3
333	27	2.9	21	1.7	16	3.2	16	1	17	3.6	12	2.7	10	.5	10	1.3
1000	19	2.4	19	4.9	13	3.1	15	1.2	14	.7	11	2.4	11	.3	12	.7
3333	21	1.7	22	4	15	.9	13	3.6	10	.3	10	2.2	12	.9	9	1.9
10000	20	1.8	18	3	16	2.3	14	2.3	12	2.7	11	2.2	10	1.2	10	1.7
Positive Control	262	12.1	445	7.8	283	18.2	178	11.5	160	5.2	251	11.3	243	5.2	62	4.3

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	117	1.5	128	6.1	128	5.2	135	1.3	132	4.8	128	4.7
100	114	8.6	140	4.2	138	2.8	142	4.4	126	4.1	155	13.5
333	121	5	140	12.3	129	4	127	2.5	138	6.8	119	4.9
1000	126	10.7	148	4.2	141	4.3	128	.9	134	4.1	137	8.7
3333	112	6.2	128	3.5	137	.9	134	5.8	142	5.5	129	2.6
10000	118	7.6	128	5.1	121	3.5	128	1.2	137	4.3	122	7.8
Positive Control	842	26.1	542	14.7	1058	75.8	2127	86.6	2774	68.6	1528	9.5

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	18	3.1	30	3.4	41	1.3	42	2.3	36	3.5	29	2.1
100	23	1.2	31	.9	46	2.4	40	2.6	34	3.8	27	1.5
333	26	4.1	33	2.1	47	1.9	35	1.7	27	4.2	31	3.7
1000	22	2.6	29	2.4	35	6.5	43	1.2	29	3.3	32	3.5
3333	14	2.9	30	1.5	45	1.2	32	2.6	34	2.3	41	2.3
10000	22	6.8	29	1.3	46	5.3	38	1.9	29	2.7	31	.9
Positive Control	362	19.3	363	28.2	305	17.3	273	9.7	559	13.2	385	15.4

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;