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Study Information
Study Attribute Value
CEBS Accession Number: 002-02167-0003-0000-1
Chemical Name: Ethylenediamine
CASRN: 107-15-3
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 414798
Vehicle Control: Water
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Equivocal) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 108 3.2 111 3 106 1.2 
33         
 106 11.9 97 2.2 80 3.8 
100         
 101 1.2 109 .8 96 4.7 
333         
 119 s 2.3 102 2.3 103 3.5 
1000         
 160 s 9.9 108 s 4.8 109 s 6.7 
2000         
 186 s 18.8 120 s 7.1 114 s 3.5
Positive Control 519 11.4 921 46.2 490 7.3

Strain: TA1535
Dose No Activation
(Negative) 		5% RLI
(Weakly Positive) 		5% HLI
(Weakly Positive) 		30% RLI
(Weakly Positive) 		30% HLI
(Equivocal) 		10% RLI
(Positive) 		10% RLI
(Weakly Positive) 		10% HLI
(Weakly Positive) 		10% HLI
(Weakly Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 25 2.4 12 1.5 11 .9 11 2.7 17 3.3 11 2.1 11 2.3 11 2.6 11 .9 
33         
 19 1 16 .7 10 1.8 18 1.9 13 1.5 12 .9 7 1.9 13 5.4 12 2 
100         
 26 .7 13 2 14 1.8 12 1.7 18 1.5 12 .7 14 3.5 17 .3 18 3.7 
333         
 29 3.8 20 1.2 24 2 25 4.9 20 1.2 21 1.2 17 4.4 19 4.1 19 1.8 
1000         
 22 s .6 24 s 1.2 29 s 1.2 26 1 29 1.3 32 s 1.2 34 s 7.5 33 s 2.7 28 1.5 
2000         
 32 s 4.5 29 s 4 34 s 9.1 37 4.9 41 s 3 53 s 5.9 37 s 0 39 s 6.7 
3333         
 37 s 2.6
Positive Control 316 16.8 237 41.6 111 1.9 88 11.7 78 5.5 219 8.2 208 10.8 48 3.2 51 7.1

Strain: TA97
Dose No Activation
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 90 .3 119 4.7 76 8 
33         
 83 6 114 2.2 100 9.2 
100         
 83 5.9 104 11.5 92 6.8 
333         
 98 2.3 114 5.5 90 8 
1000         
 87 s .5 100 s 3.2 97 s 2.1 
2000         
 77 s 4.7 75 s 1.7 101 s 2.8
Positive Control 1413 28.9 238 16.7 312 9.6

Strain: TA98
Dose No Activation
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 19 1.5 33 1.7 33 1.2 
33         
 18 1.8 28 5.5 25 1.9 
100         
 18 2.3 27 2.6 27 3.2 
333         
 17 1.5 33 3.8 25 1.7 
1000         
 17 s 2.9 27 s 3.8 33 s 1.5 
2000         
 13 s 2.1 12 s 1.7 13 s 2.4
Positive Control 212 16.8 253 2.4 148 8.3

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;