Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02227-0001-0000-6
Chemical Name:	Gum Arabic
CASRN:	9000-01-5
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	421947
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	92	5.9	144	17.3	91	7	115	1.9	141	16.5	138	5.2
100	92	6	139	4	94	7.4	94	3.8	131	9.6	122	6.9
333	102	6.6	129	6.8	100	4	121	2.9	139	15.6	124	12.5
1000	96	2.7	151	8	87	4.7	109	3.2	138	2.1	119	4.7
3333	123	3.5	127	.9	104	.9	104	4.6	136	16.1	124	4.7
10000	99	7.4	117	6.7	100	6.4	108	5.4	146	11.1	104	3.3
Positive Control	360	14.7	367	12	404	32.9	579	21.7	594	44	1197	48.6

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	24	3.5	37	3.8	15	2.3	14	.6	12	2.5	14	3.2
100	22	2.7	33	2	16	1.2	18	1.2	10	1.9	10	2.2
333	23	2	34	3	13	2.4	17	.9	11	.7	9	.9
1000	26	3.5	30	2.1	17	1.3	15	1.8	8	.9	11	.3
3333	30	3.9	34	2.3	16	2.2	15	1.7	10	1.2	9	2.6
10000	22	4.2	33	.6	18	3.2	14	2.1	10	.7	6	1.9
Positive Control	441	54.8	317	6.3	159	31.2	391	24.9	120	4.4	190	13.6

Strain: TA1537
Dose	No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	1.8	13	3.2	13	2.1
100	9	2.1	8	.6	16	.7
333	8	2.3	10	2.4	14	3.2
1000	13	4	15	1.2	14	2
3333	9	3.2	14	3.5	11	1.2
10000	9	1.7	13	4.3	9	2.7
Positive Control	818	70	41	.6	78	1.8

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	139	8.9	190	6	193	18.3	187	10.5	186	6.4	173	10.6
100	155	10.9	187	8.3	200	1.5	185	22.1	221	7	202	2.9
333	153	4.4	185	11.1	201	4.4	180	9.8	211	4.7	199	4.3
1000	169	2.8	184	2.9	210	14	197	5	204	14.9	193	9.3
3333	160	6.4	172	8.7	175	19.5	206	2.6	196	11	161	12
10000	164	5	179	7	197	6.4	189	6.7	202	7.5	180	13.4
Positive Control	615	12.3	765	16.6	355	13.2	536	21.8	519	25.6	967	27.8

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	14	1.2	18	2.4	29	1.5	23	3.7	32	.7	31	2.9
100	17	1.2	23	5.2	34	2.1	24	1.7	34	4.2	33	2.3
333	18	1	19	1	49	4.1	29	2	32	1.5	35	4.3
1000	16	1.5	21	2.3	45	5.7	24	2.3	28	.6	28	1.7
3333	15	.3	17	1.5	40	1.9	33	3.2	29	.7	31	1.2
10000	13	1.5	20	.9	47	3.8	28	.3	27	2.7	29	2.3
Positive Control	558	20.6	598	20.6	170	11.3	454	62.7	379	39.7	847	61.7

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;