Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02251-0002-0000-4
Chemical Name:	Hexamethyldisilazane
CASRN:	999-97-3
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	A99835
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	114	7.2	123	13.3	116	4.1	130	2	155	6.2	155	6.2
100	115	5.6	122	4.4	115	8.7	109	2.8	154	2.8	151	6.3
333	117	4.4	133	11.5	102	4.5	101	2.7	163	5.9	164	8.4
1000	117	1.9	117	4.2	104	3.1	110	.6	140	13	173	7.4
3333	121	3.5	129	5.3	111	1.7	102	6.5	164	10.6	164	6.9
10000	110	6.7	97	9	105	7.3	107	7.9	141	11.1	136	12.7
Positive Control	882	20.3	734	9.2	425	32.8	495	20.3	473	38.9	564	24.7

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	10	1	11	1.9	14	.7	12	1.7	10	1.2	10	.9
100	10	.3	9	1.5	11	1.3	10	.9	10	1.3	10	1.2
333	10	1.2	11	2.5	12	.3	10	.3	9	.3	10	1.3
1000	10	.3	8	.9	11	1.7	10	1.2	10	2.7	9	.3
3333	11	.6	10	.3	10	.3	12	1.2	11	1.7	9	1
10000	13	1.7	10	1.2	12	1.2	10	.9	11	2.4	9	1.9
Positive Control	830	11.6	671	22.1	165	9	190	6.6	169	8.7	175	13.5

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	157	4.7	124	1.7	195	10.2	185	3.6	156	13.3	146	2.5
100	155	6.7	129	19.7	182	17.2	186	9.6	139	7.3	171	8.4
333	156	8.7	124	4.4	193	13.9	193	9.8	145	9.4	162	12.7
1000	170	3.2	116	3.5	200	7.8	188	5.8	143	4.5	156	6.9
3333	152	12.5	134	7.4	190	6.7	188	13.9	149	4.4	169	5.5
10000	163	12	114	2.1	156	20	180	3.4	161	11.7	157	3.5
Positive Control	532	14.1	454	46.5	867	76.9	987	43.3	780	26.7	708	32.2

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	21	1.9	22	4.7	19	2.1	22	2.8	11	2.3	14	.9
100	19	2.7	19	2.7	28	1.3	22	1.3	14	2.5	12	3.7
333	13	2	16	1.5	20	2.1	23	1.7	14	3.5	15	1.8
1000	18	4.5	17	2	25	2.7	18	1	14	2.4	18	.9
3333	15	3.2	17	1.5	23	2.5	23	1.7	13	2.9	17	1
10000	18	6.2	18	2.8	16	3.8	25	0	10	1.2	9	1.3
Positive Control	311	3.8	344	2.3	471	26.3	481	14.9	233	3.8	268	22.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;