Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02309-0001-0000-7
Chemical Name:	Isobutylamine
CASRN:	78-81-9
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	043466
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	113	6.3	84	3.8	164	12.8	92	5.7	148	8	112	4.2
100	118	2.3	91	4.1	138	12.5	86	.9	140	2.6	99	4.9
333	120	6.7	99	.3	146	1.7	89	11	162	6.9	92	5.6
1000	118	7.1	80	3.8	144	7.9	76	6.7	160	9.3	100	1.8
3333	96	1	83	1.5	128	6.2	83	2.9	127	9.1	88	2.7
10000	80	2.6	79	.9	102	5.5	79	1.7	84	5.7	82	4
Positive Control	869	36.5	1298	35	1092	35.5	2659	70.2	691	34.1	1540	61.1

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	4	1.5	9	.9	7	1.7	10	1.7	6	0	20	2.1
33							12	2.1			22	3.8
100	4	.6	7	.3	5	.9	13	.7	6	.9	22	3.8
333	5	1.5	6	.7	5	.9	10	2.3	5	.3	20	4.7
1000	5	1.5	5	.9	6	.3	9	.3	7	1.8	22	3.2
3333	3	.6	7	1.7	4	3	12	1.3	4	1.9	8	2.5
10000	t		6	1	t				t
Positive Control	446	18	954	9.1	60	8.4	160	23.1	97	15.5	343	27.3

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	10	1.2	7	3	12	1.5	7	3.2	15	1.5	11	2.5
33			4	1.2			12	2.8			16	1.8
100	3	1.3	6	.6	9	2.2	8	.7	15	1.3	11	1
333	8	.9	5	1.5	9	1.5	10	1.2	15	4.8	10	.6
1000	11	0	6	1.3	12	.7	11	.3	15	2.7	13	1.2
3333	4	.3	4	.9	3	2.1	9	1.5	16	4	11	1.3
10000	0	0			0	0			0	0
Positive Control	177	104.5	57	15.6	122	43.3	39	7.2	197	15.3	180	14.4

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	19	1.2	11	1.5	44	2.2	21	1.8	35	4.4	21	3
100	22	2	11	2	39	1.2	20	.6	31	2	17	4
333	22	1.5	13	.9	35	4.2	17	2.4	36	.3	14	2.6
1000	23	2.7	13	.3	32	3	12	2.1	36	2.6	20	2.9
3333	23	.6	13	1.5	34	2	12	3.1	25	3.2	10	2.5
10000	13	.3	12	.9	18	1	9	1.3	13	2.5	14	1.2
Positive Control	109	5.2	115	6.1	527	71.3	2047	75.8	355	18.5	966	67.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;