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Study Information
Study Attribute Value
CEBS Accession Number: 002-02329-0001-0000-9
Chemical Name: Isopropyl glycidyl ether
CASRN: 4016-14-2
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 508505
Vehicle Control: Water
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Positive) 		No Activation
(Positive) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 87 4.7 85 4 133 4.7 130 9.2 132 5.5 115 10.7 
100         
 116 3.6 99 6.1 177 13.8 137 2.6 160 11.9 161 11.1 
333         
 135 12.1 119 5.2 181 11.9 183 2 163 15.2 178 14.2 
1000         
 426 28.9 359 11.4 565 31.9 557 6.3 537 27.6 561 41 
3333         
 859 115.9 636 11.7 1031 143 988 30.3 805 52.9 908 54.7 
10000         
 t t 650 118.2 2134 68.1 600 153.6 1788 36.1
Positive Control 406 62.6 395 51.5 951 151.4 1539 210.6 2510 81.9 1650 39.4

Strain: TA1535
Dose No Activation
(Positive) 		No Activation
(Positive) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 15 1.5 9 1.3 23 2.2 12 2.6 17 1.2 13 2.1 
100         
 24 .3 13 2.4 27 1 15 4.2 29 2.2 22 2.4 
333         
 21 3.3 16 4.2 28 2.1 27 2.5 28 4.3 26 .6 
1000         
 41 3.1 33 3.2 64 2.6 74 10.4 66 10 70 5.6 
3333         
 55 10.1 60 8.7 103 3.8 100 4.8 95 14.8 90 6.7 
10000         
 56 11.3 86 7.5 107 22.1 122 13.9 134 6.4 134 1.2
Positive Control 335 48.5 475 35.7 50 10 73 5 89 15.6 84 10.2

Strain: TA1537
Dose No Activation
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 6 1.2 13 1.7 11 .3 
100         
 6 1.9 11 .6 11 3.1 
333         
 6 1.5 12 1.5 11 3.5 
1000         
 8 .3 15 2.9 15 .6 
3333         
 6 .5 16 2 13 2.1 
10000         
 t 11 2.1 t
Positive Control 105 62.8 46 8.3 59 4.8

Strain: TA98
Dose No Activation
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 13 .9 28 2.2 18 2.9 
100         
 19 .3 21 1.5 17 1.9 
333         
 14 1.5 25 1.2 13 .9 
1000         
 18 4.6 27 2.3 29 1.5 
3333         
 t 38 2.6 28 3.2 
10000         
 t 39 3.5 t
Positive Control 133 25.9 534 121.7 2084 252.4

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;