Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02389-0001-0000-5
Chemical Name:	Maltol
CASRN:	118-71-8
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	944206
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Weakly Positive

View Study Details | View Protocol | Download To Excel | View Summary Data | View Detailed Data

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		20% RLI (Negative)		20% HLI (Equivocal)		10% RLI (Equivocal)		10% RLI (Equivocal)		10% HLI (Equivocal)		10% HLI (Equivocal)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	110	11.1	170	5.8	120	7.3	108	5.5	126	14.5	147	2.8	110	4.3	164	9.8
33	100	12.1
100	119	6.2	151	2.6					119	3			96	2.7
333	122	11.7	176	10					128	10.4	156	6.2	129	3.5	164	4.1
1000	141	15.8	171	4.6	128	1	124	18	121	9.9	186	13.4	123	7.8	186	2.4
2000			183	13	137	7.2	145	9.9
3333	52	7.1	192	25.2	152	14.6	150	11.6	171	9	224	11.7	181	6.4	231	6.4
4000					151	3.9	158	16.8
5000					88	2	133	10.1
6667											55	5.2			80	12.4
10000									13	5.5	1	1	3	1.3	3	1.5
Positive Control	1232	65.4	1580	36.1	655	23.7	660	35.6	678	38.7	1510	100	830	4.1	1119	41.7

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		20% RLI (Weakly Positive)		20% HLI (Positive)		10% RLI (Equivocal)		10% RLI (Weakly Positive)		10% HLI (Equivocal)		10% HLI (Equivocal)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	28	2.8	33	3.2	14	1.9	13	1	8	.3	11	.6	7	1.5	9	1.2
33	30	1.5
100	23	1.3	31	4.1					9	.6			13	1.5
333	22	4	29	2.1					12	.9	9	.3	14	1.5	14	2
1000	19	2	23	.7	14	1.2	11	1.5	12	.3	13	1.7	12	1.5	9	1.2
2000			20	2	15	3.6	18	1
3333	17	0	21	.7	26	3.1	52	2.3	18	4.4	22	1.8	21	3	28	2.3
4000					24	.7	61	1
5000					34	.9	33	3.5
6667											20	.7			8	2.5
10000									9	2	2	.3	1	.6	1	.6
Positive Control	965	28.9	1276	48.2	109	9.1	142	6.1	69	3.5	106	7.8	117	2.6	109	6.4

Strain: TA1537
Dose	No Activation (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	1.2	7	.6	10	.7
33	8	3.2
100	7	1	9	1	11	2.8
333	7	1.7	10	1	9	3.5
1000	6	.7	8	2.3	13	2.4
3333	6	.9	9	1.5	9	3
10000			7	2.7	4	0
Positive Control	212	35.4	63	10.7	73	4.1

Strain: TA98
Dose	No Activation (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	16	3	23	4.1	27	2.8
33	20	1.7
100	18	6.2	21	.9	27	3
333	22	.3	30	5	29	0
1000	16	4.3	33	3.6	25	4.8
3333	17	4.4	25	3.2	32	4
10000			11	1.8	5	1.2
Positive Control	1582	50.1	340	12.9	412	5.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;