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Study Information
Study Attribute Value
CEBS Accession Number: 002-02644-0005-0000-3
Chemical Name: Pentachlorophenol, Dowicide EC-7
CASRN: 87-86-5
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A54434
Strain and Species: B6C3F1 Mouse
Study Result: Male: Negative

Bone Marrow

Start Date Sample Collection Time Sex Methodology Used Route Dosing Regimen
1993-09-28 24 hour Male Slide Scoring Gavage Gavage x 3, 72 hour
  Dose
(mg/kg)		 Animal
Number		 Polychromatic Erythrocytes
Trend P: 0.698
No. Examined Total MN Cells Percent PCE MN Cells
per 1000
Vehicle Control Corn Oil 
 0         
 6267 2000 5 43.5 2.5 
 0         
 6269 2000 6 65.0 3.0 
 0         
 6273 2000 2 53.5 1.0 
 0         
 6282 2000 4 59.5 2.0 
 0         
 6283 2000 5 57.5 2.5
Average ± SEM   55.800 ± 3.590 2.200 ± 0.340
 
Test Chemical Pentachlorophenol, Dowicide EC-7 
50         
 6261 2000 2 64.5 1.0 
50         
 6262 2000 42 60.0 21.0 
50         
 6263 2000 2 53.5 1.0 
50         
 6270 2000 2 46.0 1.0 
50         
 6272 2000 20 49.5 10.0 
50         
 6274 0 0 0 0.0 
50         
 6275 2000 31 24.0 15.5 
50         
 6277 0 0 0 0.0 
50         
 6278 0 0 0 0.0 
50         
 6279 2000 50 47.5 25.0
Average ± SEM   54.670 ± 5.370 1.000 ± 0.000
Pairwise P   0.961
 
Test Chemical Pentachlorophenol, Dowicide EC-7 
100         
 6264 0 0 0 0.0 
100         
 6265 0 0 0 0.0 
100         
 6271 2000 7 52.5 3.5 
100         
 6281 2000 2 70.0 1.0 
100         
 6285 2000 3 60.5 1.5
Average ± SEM   61.000 ± 5.060 2.000 ± 0.760
Pairwise P   0.605
 
Test Chemical Pentachlorophenol, Dowicide EC-7 
150         
 6266 0 0 0.0 
150         
 6268 0 0 0.0 
150         
 6276 0 0 0.0 
150         
 6280 0 0 0.0 
150         
 6284 0 0 0.0
Average ± SEM   0.000 ± 0.000 0.000 ± 0.000
 
Positive Control Cyclophosphamide 
50         
 6261 2000 2 64.5 1.0 
50         
 6262 2000 42 60.0 21.0 
50         
 6263 2000 2 53.5 1.0 
50         
 6270 2000 2 46.0 1.0 
50         
 6272 2000 20 49.5 10.0 
50         
 6274 0 0 0 0.0 
50         
 6275 2000 31 24.0 15.5 
50         
 6277 0 0 0 0.0 
50         
 6278 0 0 0 0.0 
50         
 6279 2000 50 47.5 25.0
Average ± SEM   45.250 ± 7.600 17.880 ± 3.270
Pairwise P   Value less than 0.0001