| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02644-0006-0000-4 |
| Chemical Name: | Pentachlorophenol, Dowicide EC-7 |
| CASRN: | 87-86-5 |
| NTP Study Type: | Genetic Toxicology - Micronucleus |
| NTP Study ID: | A84354 |
| Strain and Species: | Fischer 344 Rat |
| Study Result: | Male: Negative |
Bone Marrow
| Start Date | Sample Collection Time | Sex | Methodology Used | Route | Dosing Regimen |
|---|---|---|---|---|---|
| 1993-08-17 | 24 hour | Male | Slide Scoring | Gavage | Gavage x 3, 72 hour |
| Dose (mg/kg) |
Animal Number |
Polychromatic Erythrocytes Trend P: 0.062 |
|||||
|---|---|---|---|---|---|---|---|
| No. Examined | Total MN Cells | Percent PCE | MN Cells per 1000 |
||||
| Vehicle Control | Corn Oil | 0 |
6241 | 2000 | 0 | 36.0 | 0.0 |
0 |
6249 | 2000 | 3 | 35.5 | 1.5 | ||
0 |
6256 | 2000 | 2 | 52.5 | 1.0 | ||
0 |
6259 | 2000 | 0 | 35.5 | 0.0 | ||
0 |
6260 | 2000 | 3 | 39.5 | 1.5 | ||
| Average ± SEM | 39.800 ± 3.260 | 0.800 ± 0.340 | |||||
| Test Chemical | Pentachlorophenol, Dowicide EC-7 | 25 |
6234 | 0 | 0 | 0 | 0.0 |
25 |
6236 | 2000 | 26 | 5.5 | 13.0 | ||
25 |
6237 | 2000 | 2 | 21.0 | 1.0 | ||
25 |
6239 | 2000 | 23 | 12.0 | 11.5 | ||
25 |
6242 | 2000 | 35 | 9.0 | 17.5 | ||
25 |
6243 | 2000 | 0 | 23.5 | 0.0 | ||
25 |
6247 | 2000 | 1 | 39.0 | 0.5 | ||
25 |
6248 | 2000 | 3 | 8.0 | 1.5 | ||
25 |
6254 | 2000 | 3 | 18.0 | 1.5 | ||
25 |
6255 | 2000 | 50 | 24.5 | 25.0 | ||
| Average ± SEM | 25.380 ± 4.680 | 0.750 ± 0.320 | Pairwise P | 0.548 | |||
| Test Chemical | Pentachlorophenol, Dowicide EC-7 | 50 |
6235 | 2000 | 5 | 23.0 | 2.5 |
50 |
6240 | 2000 | 4 | 45.5 | 2.0 | ||
50 |
6245 | 2000 | 2 | 34.5 | 1.0 | ||
50 |
6257 | 2000 | 3 | 19.0 | 1.5 | ||
50 |
6258 | 2000 | 1 | 28.5 | 0.5 | ||
| Average ± SEM | 30.100 ± 4.650 | 1.500 ± 0.350 | Pairwise P | 0.072 | |||
| Test Chemical | Pentachlorophenol, Dowicide EC-7 | 75 |
6238 | 0 | 0 | 0.0 | |
75 |
6244 | 0 | 0 | 0.0 | |||
75 |
6246 | 0 | 0 | 0.0 | |||
75 |
6250 | 0 | 0 | 0.0 | |||
75 |
6252 | 0 | 0 | 0.0 | |||
75 |
6253 | 0 | 0 | 0.0 | |||
| Average ± SEM | 0.000 ± 0.000 | 0.000 ± 0.000 | |||||
| Positive Control | Cyclophosphamide | 25 |
6234 | 0 | 0 | 0 | 0.0 |
25 |
6236 | 2000 | 26 | 5.5 | 13.0 | ||
25 |
6237 | 2000 | 2 | 21.0 | 1.0 | ||
25 |
6239 | 2000 | 23 | 12.0 | 11.5 | ||
25 |
6242 | 2000 | 35 | 9.0 | 17.5 | ||
25 |
6243 | 2000 | 0 | 23.5 | 0.0 | ||
25 |
6247 | 2000 | 1 | 39.0 | 0.5 | ||
25 |
6248 | 2000 | 3 | 8.0 | 1.5 | ||
25 |
6254 | 2000 | 3 | 18.0 | 1.5 | ||
25 |
6255 | 2000 | 50 | 24.5 | 25.0 | ||
| Average ± SEM | 11.800 ± 3.340 | 13.700 ± 3.850 | Pairwise P | Value less than 0.0001 | |||