Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02700-0003-0000-4
Chemical Name:	Piperonal acetone
CASRN:	3160-37-0
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	811284
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	131	5.2	153	6.2	137	11.4	137	6.5	132	2.3	155	1.5
10	129	5.7	147	3.7
33	133	6.8	149	6.6	142	5.3	145	3.3	142	1	151	10.4
100	144	7.2	153	11.7	134	7	136	2.6	134	7.2	154	5.4
333	156	14.4	169	5.9	131	3.4	148	4.3	136	12.6	153	1.2
900			157 s	5.7
1000	101 s	2			146	7.2	145	5.5	150	4.9	138	8.6
3000							t
3333					t				143 s	1.5	131 s	8.3
Positive Control	1514	37.6	1504	77	746	12.5	1616	6.7	1758	34.5	1106	30.1

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	19	2.9	35	0	8	1	7	.3	6	1.2	8	.3
10	20	2.9	24	3.5
33	23	2.6	23	3.1	8	3.5	9	2	8	1.5	10	.9
100	22	3.3	25	1.8	12	1.8	7	2.5	11	1.5	7	.9
333	27	3	25	2.3	13	2.2	7	1.2	11	1.2	7	1.5
900			9 s	.7
1000	10 s	1.5			12	1.5	9	1.3	11	2.6	10	.9
3000							t
3333					t				11 s	1.5	7 s	.9
Positive Control	1163	34.5	1218	18.2	76	6.8	88	4.7	130	2.8	85	3.3

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	4	1.9	6	1	6	.9	10	3.7	11	1	8	1.2
10	4	1.2	5	0
33	4	.3	5	2.3	7	2.2	6	1.5	5	.6	6	1.2
100	4	.9	5	.3	8	.9	6	.3	7	1.2	8	.9
333	5	.6	5	1.2	7	.3	8	.9	5	1	7	1.7
900			6 s	2.2
1000	5 s	.5			9	1.8	8	.6	6	1.8	8	1.3
3000							t
3333					7 s	.5			6 s	1	8 s	2.7
Positive Control	144	11.8	639	39.2	64	7.9	150	8.9	222	6.9	75	9.1

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	21	.9	17	3.5	28	5.5	27	2.5	29	.3	22	.3
10	16	1.9	13	1.2
33	17	2.3	15	2.7	25	4.4	29	3.1	27	1.5	24	1.2
100	21	4.3	12	1.2	25	3.1	24	4.5	22	.7	27	.9
333	15	1.3	15	2	23	.9	28	1.7	23	2.9	25	.6
900			11 s	3.5
1000	10 s	.7			20	3	24	1.5	31	2.4	29	.3
3000							t
3333					12 s	0			29 s	3.8	25 s	1.2
Positive Control	1344	55.2	1479	46.2	490	18.4	1275	75	1114	104.1	808	32.6

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;