Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02905-0001-0000-9
Chemical Name:	Thioglycolic acid
CASRN:	68-11-1
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	301735
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	91	3.2	129	5	133	8.7	109	4.7	100	3.7	83	9
33	91	10.1	108	9.9	103	2.2	111	7.9	90	7.2	85	1.5
100	92	6.7	113	9.2	127	6.4	100	11.9	94	7.2	77	2.5
333	81	1.3	113	6.9	101	8.1	89	4.4	107	9.3	101	3.3
1000	78	2.3	88	4.7	123	7.5	104	1.7	89	3	87	7.5
2000					90 s	3	88 s	8.3	63	5.8	63	9.6
3333	2 s	.9	39 s	6.3
Positive Control	1407	48.6	1122	27.6	416	10.4	400	39.4	1218	11.7	1373	25.2

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	30	4.9	43	3.4	17	2.6	15	3.2	13	1.5	11	1.2
33	26	3.2	38	7.8	14	0	15	1.5	7	.3	7	1.5
100	28	4.2	41	1.2	14	3.1	16	1.7	11	1.5	9	1.5
333	23	1.8	41	4.3	14	2.5	12	2.3	9	.3	9	2.3
1000	9	4.9	28	5	11	.9	11	2	9	.9	7	1.2
2000					10 s	2	10 s	1.2	6	2	10	1.2
3333	1 s	.3	13 s	1.5
Positive Control	1065	17.4	531	10.7	121	8.4	154	5.9	89	2	122	11.5

Strain: TA97
Dose	No Activation (Negative)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	89	3.8	59	2	152	1.2	130	19.9	126	9.9	132	5.3
33	99	9.8	72	2.7	136	6.4	127	3.5	139	3.8	125	12.5
100	85	5.8	78	4.9	147	1.5	136	1	121	7.2	144	10.9
333	109	8.2	80	1.2	153	7.5	154	1.3	131	7	117	19.2
1000	25	8.7	27 s	8.3	159	3.5	159 s	5.9	152	9.7	155	3.1
2000					49 s	5.9	41 s	6.6	2	2.3	6	1.5
3333	0 s	0	1 s	.7
Positive Control	497	11.7	214	16.3	344	24.4	342	11.8	780	9.5	794	8.4

Strain: TA98
Dose	No Activation (Equivocal)		No Activation (Negative)		30% RLI (Negative)		30% HLI (Negative)		10% RLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	10	2.3	21	.3	32	2	37	2.4	28	1.5	32	3.6
33	16	3.5	18	4.3	32	5	36	1.5	36	5.2	33	2
100	12	3.2	17	6.5	33	3	33	2	28	5.8	38	6.2
333	13	2.4	15	1.7	40	5.5	40	3.8	27	2.4	27	.7
1000	21	1	20 s	2.2	34	3.2	36	3.1	29	1.3	32	2.2
2000					36 s	4.4	33 s	1.3	26	2.5	23	1.2
3333	5 s	2.1	19 s	1.3
Positive Control	1548	13	1243	28.1	296	6.6	346	2.3	1352	8.7	1631	83

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;